Serge Pieters
Overview
Explore the profile of Serge Pieters including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
75
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Carney S, Grosse S, Yin Y, Tran M, Kalin J, Jacoby E, et al.
J Med Chem
. 2025 Mar;
PMID: 40042938
Respiratory syncytial virus (RSV) remains a public health burden due to unmet therapeutic needs. We recently reported the discovery of a non-nucleoside inhibitor of the RSV polymerase and characterized its...
2.
Tran M, Grosse S, Carbajo R, Jacoby E, Yin Y, Yu X, et al.
ACS Med Chem Lett
. 2024 Sep;
15(9):1549-1558.
PMID: 39291020
Despite the availability of medicines preventing respiratory syncytial virus (RSV) infection, post-exposure treatment options are needed for addressing patient's needs. RSV non-nucleoside polymerase inhibitors (NNI) have emerged as a promising...
3.
Kesteleyn B, Herschke F, Darville N, Stoops B, Jacobs T, Jacoby E, et al.
J Med Chem
. 2024 Jun;
67(13):10986-11002.
PMID: 38932487
Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants, the elderly, and immune-compromised patients. While a half-life extended monoclonal antibody and 2 vaccines have recently been approved...
4.
Taylor A, Beauchamp J, Briand L, Heer M, Hummel T, Margot C, et al.
Compr Rev Food Sci Food Saf
. 2020 Dec;
19(6):3439-3475.
PMID: 33337044
The intention to send a crewed mission to Mars involves a huge amount of planning to ensure a safe and successful mission. Providing adequate amounts of food for the crew...
5.
Bischoff F, Velter A, Minne G, Pieters S, Berthelot D, De Cleyn M, et al.
Bioorg Med Chem Lett
. 2019 May;
29(14):1737-1745.
PMID: 31122869
The discovery, design and synthesis of a new series of GSMs is described. The classical imidazole heterocycle has been replaced by a cyano group attached to an indole nucleus. The...
6.
Embrechts W, Herschke F, Pauwels F, Stoops B, Last S, Pieters S, et al.
J Med Chem
. 2018 Jul;
61(14):6236-6246.
PMID: 29965759
A novel series of 2,4-diaminoquinazolines was identified as potent dual Toll-like receptor (TLR) 7 and 8 agonists with reduced off-target activity. The stereochemistry of the amino alcohol was found to...
7.
Pieters S, McGowan D, Herschke F, Pauwels F, Stoops B, Last S, et al.
Bioorg Med Chem Lett
. 2018 Jan;
28(4):711-719.
PMID: 29366653
The discovery of a novel series of highly potent quinazoline TLR 7/8 agonists is described. The synthesis and structure-activity relationship is presented. Structural requirements and optimization of this series toward...
8.
McGowan D, Herschke F, Pauwels F, Stoops B, Smyej I, Last S, et al.
J Med Chem
. 2017 Jul;
60(14):6137-6151.
PMID: 28671847
Pyrrolo[3,2-d]pyrimidines were identified as a new series of potent and selective TLR7 agonists. Compounds were optimized for their activity and selectivity over TLR8. This presents an advantage over recently described...
9.
McGowan D, Herschke F, Pauwels F, Stoops B, Last S, Pieters S, et al.
J Med Chem
. 2016 Aug;
59(17):7936-49.
PMID: 27513093
Toll-like receptor (TLR) 7 and 8 agonists can potentially be used in the treatment of viral infections and are particularly promising for chronic hepatitis B virus (HBV) infection. An internal...
10.
Velter A, Bischoff F, Berthelot D, De Cleyn M, Oehlrich D, Jaroskova L, et al.
Bioorg Med Chem Lett
. 2014 Dec;
24(24):5805-5813.
PMID: 25454273
The design and synthesis of a novel series of potent gamma secretase modulators is described. Exploration of various spacer groups between the triazole ring and the aromatic appendix in 2...