Serene C Chng
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Explore the profile of Serene C Chng including associated specialties, affiliations and a list of published articles.
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8
Citations
576
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Recent Articles
1.
Reversade B, Escande-Beillard N, Dimopoulou A, Fischer B, Chng S, Li Y, et al.
Nat Genet
. 2022 Jan;
54(2):213.
PMID: 35064218
No abstract available.
2.
Ho L, van Dijk M, Chye S, Messerschmidt D, Chng S, Ong S, et al.
Science
. 2017 Jul;
357(6352):707-713.
PMID: 28663440
Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal morbidity and mortality, its molecular...
3.
Perez-Camps M, Tian J, Chng S, Sem K, Sudhaharan T, Teh C, et al.
Elife
. 2016 Sep;
5.
PMID: 27684073
Formation of the three embryonic germ layers is a fundamental developmental process that initiates differentiation. How the zebrafish pluripotency factor Pou5f3 (homologous to mammalian Oct4) drives lineage commitment is unclear....
4.
Deshwar A, Chng S, Ho L, Reversade B, Scott I
Elife
. 2016 Apr;
5.
PMID: 27077952
The Apelin receptor (Aplnr) is essential for heart development, controlling the early migration of cardiac progenitors. Here we demonstrate that in zebrafish Aplnr modulates Nodal/TGFβ signaling, a key pathway essential...
5.
Ho L, Tan S, Wee S, Wu Y, Tan S, Ramakrishna N, et al.
Cell Stem Cell
. 2015 Sep;
17(4):435-47.
PMID: 26387754
ELABELA (ELA) is a peptide hormone required for heart development that signals via the Apelin Receptor (APLNR, APJ). ELA is also abundantly secreted by human embryonic stem cells (hESCs), which...
6.
Helker C, Schuermann A, Pollmann C, Chng S, Kiefer F, Reversade B, et al.
Elife
. 2015 May;
4.
PMID: 26017639
A key step in the de novo formation of the embryonic vasculature is the migration of endothelial precursors, the angioblasts, to the position of the future vessels. To form the...
7.
Chng S, Ho L, Tian J, Reversade B
Dev Cell
. 2013 Dec;
27(6):672-80.
PMID: 24316148
We report here the discovery and characterization of a gene, ELABELA (ELA), encoding a conserved hormone of 32 amino acids. Present in human embryonic stem cells, ELA is expressed at...
8.
Reversade B, Escande-Beillard N, Dimopoulou A, Fischer B, Chng S, Li Y, et al.
Nat Genet
. 2009 Aug;
41(9):1016-21.
PMID: 19648921
Autosomal recessive cutis laxa (ARCL) describes a group of syndromal disorders that are often associated with a progeroid appearance, lax and wrinkled skin, osteopenia and mental retardation. Homozygosity mapping in...