Seppo J Vainio
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Explore the profile of Seppo J Vainio including associated specialties, affiliations and a list of published articles.
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61
Citations
866
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Recent Articles
1.
Ali N, Xu Q, Prunskaite-Hyyrylainen R, Shan J, Vainio S
Int J Dev Biol
. 2024 Nov;
68(4):241-249.
PMID: 39601094
Wnt4 signaling is critical for mammalian female sex determination, in female reproductive organ development, in follicular and oocyte maturation, and in steroid hormone production. When Wnt4 function is impaired, female...
2.
Oliveira M, Sarker P, Skovorodkin I, Kalantarifard A, Haskavuk T, Mac Intyre J, et al.
Lab Chip
. 2024 Sep;
24(20):4816-4826.
PMID: 39290081
Organoids are emerging as a powerful tool to investigate complex biological structures . Vascularization of organoids is crucial to recapitulate the morphology and function of the represented human organ, especially...
3.
Pratiwi F, Thomas R, Karzarjeddi M, Sarpola M, Miinalainen I, Makieieva O, et al.
Biomacromolecules
. 2024 Aug;
25(9):5847-5859.
PMID: 39190019
Plant-derived nanovesicles such as bilberries nanovesicles (BNVs) show immense promise as next-generation biotherapeutics and functional food ingredients; however, their isolation, purification, and storage on a large scale remain a challenge....
4.
Satta J, Lindstrom R, Myllymaki S, Lan Q, Trela E, Prunskaite-Hyyrylainen R, et al.
Development
. 2024 Aug;
151(15).
PMID: 39092607
Branching morphogenesis is a characteristic feature of many essential organs, such as the lung and kidney, and most glands, and is the net result of two tissue behaviors: branch point...
5.
Kankaanpaa S, Nurmi M, Lampimaki M, Leskinen H, Nieminen A, Samoylenko A, et al.
J Extracell Biol
. 2024 Jun;
3(4):e149.
PMID: 38938848
Isolation of extracellular vesicles (EV) has been developing rapidly in parallel with the interest in EVs. However, commonly utilized protocols may not suit more challenging sample matrixes and could potentially...
6.
Rinta-Jaskari M, Naillat F, Ruotsalainen H, Ronkainen V, Heljasvaara R, Akram S, et al.
Matrix Biol
. 2024 May;
131:30-45.
PMID: 38788809
Renal development is a complex process in which two major processes, tubular branching and nephron development, regulate each other reciprocally. Our previous findings have indicated that collagen XVIII (ColXVIII), an...
7.
Naillat F, Deshar G, Hankkila A, Rak-Raszewska A, Sharma A, Prunskaite-Hyyrylainen R, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Apr;
1870(5):167180.
PMID: 38653356
The renal tubular epithelial cells (TEC) have a strong capacity for repair after acute injury, but when this mechanism becomes uncontrollable, it leads to chronic kidney diseases (CKD). Indeed, in...
8.
Zhyvolozhnyi A, Samoylenko A, Bart G, Kaisanlahti A, Hekkala J, Makieieva O, et al.
Nanotheranostics
. 2024 Jan;
8(1):48-63.
PMID: 38164498
Sweat contains biomarkers for real-time non-invasive health monitoring, but only a few relevant analytes are currently used in clinical practice. In the present study, we investigated whether sweat-derived extracellular vesicles...
9.
Ahmad N, Samoylenko A, Abene I, Abdelrady E, Zhyvolozhnyi A, Makieieva O, et al.
Cell Commun Signal
. 2023 Dec;
21(1):358.
PMID: 38110951
Background: During kidney organogenesis, metanephric mesenchyme (MM) and ureteric bud (UB) interact reciprocally to form nephrons. Signaling stimuli involved in these interactions include Wnts, growth factors and nano/micro particles. How...
10.
Shanthi K, Fischer D, Sharma A, Kiviniemi A, Kaakinen M, Vainio S, et al.
Genes (Basel)
. 2023 Apr;
14(4).
PMID: 37107614
Astrocytes are central nervous system (CNS)-restricted glial cells involved in synaptic function and CNS blood flow regulation. Astrocyte extracellular vesicles (EVs) participate in neuronal regulation. EVs carry RNAs, either surface-bound...