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Seong J An

Explore the profile of Seong J An including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 114
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Recent Articles
1.
Edman N, Phal A, Redler R, Schlichthaerle T, Srivatsan S, Ehnes D, et al.
Cell . 2024 Jun; 187(14):3726-3740.e43. PMID: 38861993
Many growth factors and cytokines signal by binding to the extracellular domains of their receptors and driving association and transphosphorylation of the receptor intracellular tyrosine kinase domains, initiating downstream signaling...
2.
Edman N, Redler R, Phal A, Schlichthaerle T, Srivatsan S, Etemadi A, et al.
bioRxiv . 2023 Mar; PMID: 36993355
Growth factors and cytokines signal by binding to the extracellular domains of their receptors and drive association and transphosphorylation of the receptor intracellular tyrosine kinase domains, initiating downstream signaling cascades....
3.
An S, Mohanty J, Tome F, Suzuki Y, Lax I, Schlessinger J
Proc Natl Acad Sci U S A . 2023 Feb; 120(7):e2219128120. PMID: 36745784
While important insights were gained about how FGF21 and other endocrine fibroblast growth factors (FGFs) bind to Klotho proteins, the exact mechanism of Klotho/FGF receptor assembly that drives receptor dimerization...
4.
An S, Anneken A, Xi Z, Choi C, Schlessinger J, Toomre D
Proc Natl Acad Sci U S A . 2022 Nov; 119(48):e2208947119. PMID: 36417441
The phosphoinositide-3 kinase (PI-3K)/AKT cell survival pathway is an important pathway activated by EGFR signaling. Here we show, that in addition to previously described critical components of this pathway, i.e.,...
5.
An S, Stagi M, Gould T, Wu Y, Mlodzianoski M, Rivera-Molina F, et al.
Cell Rep Methods . 2022 May; 2(4):100199. PMID: 35497490
A complete understanding of synaptic-vesicle recycling requires the use of multiple microscopy methods to obtain complementary information. However, many currently available probes are limited to a specific microscopy modality, which...
6.
An S, Rivera-Molina F, Anneken A, Xi Z, McNellis B, Polejaev V, et al.
Nat Commun . 2021 Sep; 12(1):5434. PMID: 34521845
Vesicle tethers are thought to underpin the efficiency of intracellular fusion by bridging vesicles to their target membranes. However, the interplay between tethering and fusion has remained enigmatic. Here, through...
7.
Suzuki Y, Kuzina E, An S, Tome F, Mohanty J, Li W, et al.
Proc Natl Acad Sci U S A . 2020 Dec; 117(50):31800-31807. PMID: 33257569
The three members of the endocrine-fibroblast growth factor (FGF) family, FGF19, 21, and 23 are circulating hormones that regulate critical metabolic processes. FGF23 stimulates the assembly of a signaling complex...
8.
An S, Grabner C, Zenisek D
Nat Neurosci . 2010 Apr; 13(5):577-83. PMID: 20383135
Understanding the fundamental role of soluble NSF attachment protein receptor (SNARE) complexes in membrane fusion requires knowledge of the spatiotemporal dynamics of their assembly. We visualized complexin (cplx), a cytosolic...
9.
An S, Almers W
Science . 2004 Nov; 306(5698):1042-6. PMID: 15528447
Syntaxin, synaptosome-associated protein of 25 kD (SNAP25), and vesicle-associated membrane protein/synaptobrevin are collectively called SNAP receptor (SNARE) proteins, and they catalyze neuronal exocytosis by forming a "core complex." The steps...