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Senthil T Kumar

Explore the profile of Senthil T Kumar including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 306
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Recent Articles
1.
Altay M, Kumar S, Burtscher J, Jagannath S, Strand C, Miki Y, et al.
NPJ Parkinsons Dis . 2024 Jan; 10(1):19. PMID: 38212333
No abstract available.
2.
Altay M, Kumar S, Burtscher J, Jagannath S, Strand C, Miki Y, et al.
NPJ Parkinsons Dis . 2023 Dec; 9(1):161. PMID: 38062007
The abnormal aggregation and accumulation of alpha-synuclein (aSyn) in the brain is a defining hallmark of synucleinopathies. Various aSyn conformations and post-translationally modified forms accumulate in pathological inclusions and vary...
3.
Kavungal D, Magalhaes P, Kumar S, Kolla R, Lashuel H, Altug H
Sci Adv . 2023 Jul; 9(28):eadg9644. PMID: 37436975
Diagnosis of neurodegenerative disorders (NDDs) including Parkinson's disease and Alzheimer's disease is challenging owing to the lack of tools to detect preclinical biomarkers. The misfolding of proteins into oligomeric and...
4.
Kumar S, Nazarov S, Porta S, Maharjan N, Cendrowska U, Kabani M, et al.
Nat Neurosci . 2023 May; 26(6):983-996. PMID: 37248338
Despite the strong evidence linking the transactive response DNA-binding protein 43 (TDP-43) aggregation to the pathogenesis of frontotemporal lobar degeneration with TDP-43, amyotrophic lateral sclerosis and several neurodegenerative diseases, our...
5.
Kumar S, Mahul-Mellier A, Hegde R, Riviere G, Moons R, de Opakua A, et al.
Sci Adv . 2022 Apr; 8(17):eabn0044. PMID: 35486726
The alpha-synuclein mutation E83Q, the first in the NAC domain of the protein, was recently identified in a patient with dementia with Lewy bodies. We investigated the effects of this...
6.
Kumar S, Jagannath S, Francois C, Vanderstichele H, Stoops E, Lashuel H
Neurobiol Dis . 2020 Sep; 146:105086. PMID: 32971232
Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation, and may also accumulate within LBs in Parkinson's...
7.
Cendrowska U, Silva P, Ait-Bouziad N, Muller M, Pelin Guven Z, Vieweg S, et al.
Proc Natl Acad Sci U S A . 2020 Mar; 117(12):6866-6874. PMID: 32161130
Increasing evidence suggests that amyloid polymorphism gives rise to different strains of amyloids with distinct toxicities and pathology-spreading properties. Validating this hypothesis is challenging due to a lack of tools...
8.
Kumar S, Donzelli S, Chiki A, Syed M, Lashuel H
J Neurochem . 2020 Jan; 153(1):103-119. PMID: 31925956
Increasing evidence suggests that the process of alpha-synuclein (α-syn) aggregation from monomers into amyloid fibrils and Lewy bodies, via oligomeric intermediates plays an essential role in the pathogenesis of different...
9.
Burtscher J, Copin J, Rodrigues J, Kumar S, Chiki A, Guillot de Suduiraut I, et al.
Neurobiol Aging . 2019 Oct; 83:11-20. PMID: 31585362
Debilitating, yet underinvestigated nonmotor symptoms related to mood/emotion, such as depression, are common in Parkinson's disease. Here, we explore the role of depression and of the amygdala, a brain region...
10.
Garvey M, Baumann M, Wulff M, Kumar S, Markx D, Morgado I, et al.
Amyloid . 2016 Mar; 23(2):76-85. PMID: 26972581
Objectives: The detailed structure of brain-derived Aβ amyloid fibrils is unknown. To approach this issue, we investigate the molecular architecture of Aβ(1-40) fibrils grown in either human cerebrospinal fluid solution,...