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Sekiya Koyama

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Articles 13
Citations 118
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Recent Articles
1.
Motoki H, Inobe Y, Fukui T, Iwasaki A, Hiramitsu S, Koyama S, et al.
Adv Ther . 2023 Sep; 40(11):5055-5075. PMID: 37733211
Introduction: The EAGLE-DH study assessed the efficacy and safety of esaxerenone in hypertensive patients with diabetes mellitus receiving sodium-glucose cotransporter 2 (SGLT2) inhibitors. Methods: In this multicenter, open-label, prospective, interventional...
2.
Koyama S, Sakaguchi N, Hotta J
Rinsho Byori . 2012 Dec; 60(8):796-803. PMID: 23198540
Mycobacterium tuberculosis (M. tuberculosis) infects all organs in the body; however, lung infection is the primary lesion. The total number of infections is decreasing, but the percentage of infections in...
3.
Yamazaki Y, Ushiki A, Tanabe Y, Koyama S, Kubo K
J Infect Chemother . 2012 Feb; 18(5):683-8. PMID: 22370922
The Mycobacterium avium complex (MAC) invades cultured human bronchial cells, can replicate intracellularly, and facilitates the release of inflammatory cytokines and chemokines from cells. The purpose of this study was...
4.
Ushiki A, Yamazaki Y, Koyama S, Tsushima K, Yamamoto H, Hanaoka M, et al.
Intern Med . 2011 Jun; 50(12):1287-92. PMID: 21673463
Objective: The incidence of pulmonary Mycobacterium avium complex (MAC) infections with nodular/bronchiectasis lesions is increasing. However, factors determining deterioration are unknown. In the present study, we investigated quantitative MAC cultures...
5.
Takashi S, Park J, Fang S, Koyama S, Parikh I, Adler K
Am J Respir Cell Mol Biol . 2006 Mar; 34(6):647-52. PMID: 16543603
Leukocytes synthesize a variety of inflammatory mediators that are packaged and stored in the cytoplasm within membrane-bound granules. Upon stimulation, the cells secrete the granule contents via an exocytotic process...
6.
Numanami H, Koyama S, Nelson D, Hoyt J, Freels J, Habib M, et al.
Am J Respir Cell Mol Biol . 2003 May; 29(5):613-9. PMID: 12738688
Smoking is associated with lung inflammation and a protease-antiprotease imbalance. We previously reported that cigarette smoke extract (CSE) stimulates human lung fibroblasts to release chemotactic cytokines. We hypothesized that serine...
7.
Numanami H, Koyama S, Sato E, Haniuda M, Nelson D, Hoyt J, et al.
Am J Physiol Lung Cell Mol Physiol . 2003 Apr; 284(5):L882-90. PMID: 12676771
Chemotactic chemokines can be released from lung fibroblasts in response to interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha. An imbalance between proteases and antiproteases has been observed at inflammatory sites,...
8.
Kurai M, Yamanda T, Koyama S, Tunoda T, Gono H
Nihon Kokyuki Gakkai Zasshi . 2003 Mar; 40(11):915-8. PMID: 12645115
A 54-year-old man was admitted to our hospital with hemoptysis. Chest radiography and chest CT scanning demonstrated atelectasis in the right middle lobe. Bronchoscopy showed nothing of abnormal appearance. We...
9.
Numanami H, Nelson D, Hoyt J, Freels J, Habib M, Amano J, et al.
Am J Respir Cell Mol Biol . 2003 Mar; 29(2):239-44. PMID: 12626343
Peroxynitrite, formed by nitric oxide and superoxide, has been shown to nitrate and reduce the function of proinflammatory proteins such as interleukin (IL)-8, monocyte chemoattractant protein-1, and eotaxin, but in...
10.
Koyama S, Sato E, Takamizawa A, Tsukadaira A, Haniuda M, Kurai M, et al.
Exp Lung Res . 2003 Jan; 29(2):91-111. PMID: 12554356
Methotrexate-induced pneumonitis has been reported as an infrequent but potentially serious complication of therapy in a variety of malignant and benign conditions. Because inflammatory cell infiltration is concerned with the...