Sebastien Moreno
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Explore the profile of Sebastien Moreno including associated specialties, affiliations and a list of published articles.
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10
Citations
192
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Recent Articles
1.
Dunot J, Moreno S, Gandin C, Pousinha P, Amici M, Dupuis J, et al.
Neuron
. 2024 Jun;
112(16):2708-2720.e9.
PMID: 38878768
NMDA receptors (NMDARs) are ionotropic receptors crucial for brain information processing. Yet, evidence also supports an ion-flux-independent signaling mode mediating synaptic long-term depression (LTD) and spine shrinkage. Here, we identify...
2.
Dainauskas J, Vitale P, Moreno S, Marie H, Migliore M, Saudargiene A
Front Comput Neurosci
. 2023 Dec;
17:1305169.
PMID: 38130706
Alzheimer's disease (AD) is a progressive memory loss and cognitive dysfunction brain disorder brought on by the dysfunctional amyloid precursor protein (APP) processing and clearance of APP peptides. Increased APP...
3.
Rajao-Saraiva J, Dunot J, Ribera A, Temido-Ferreira M, Coelho J, Konig S, et al.
Aging Cell
. 2023 Jan;
22(3):e13778.
PMID: 36704841
N-methyl-D-aspartate receptors (NMDARs) are critical for the maturation and plasticity of glutamatergic synapses. In the hippocampus, NMDARs mainly contain GluN2A and/or GluN2B regulatory subunits. The amyloid precursor protein (APP) has...
4.
Moreno S, Devader C, Pietri M, Borsotto M, Heurteaux C, Mazella J
Front Pharmacol
. 2018 Aug;
9:863.
PMID: 30127743
The background potassium channel TREK-1 has been shown to be a potent target for depression treatment. Indeed, deletion of this channel in mice resulted in a depression resistant phenotype. The...
5.
Djillani A, Pietri M, Moreno S, Heurteaux C, Mazella J, Borsotto M
Front Pharmacol
. 2017 Sep;
8:643.
PMID: 28955242
Depression is a devastating mental disorder that affects 20% of the population worldwide. Despite their proven efficacy, antidepressants present a delayed onset of action and serious adverse effects. Seven years...
6.
Hivelin C, Beraud-Dufour S, Devader C, Abderrahmani A, Moreno S, Moha Ou Maati H, et al.
J Diabetes Res
. 2017 Jan;
2016:3142175.
PMID: 28105440
Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic...
7.
Devader C, Moreno S, Roulot M, Deval E, Dix T, Morales C, et al.
Front Neurosci
. 2016 Dec;
10:542.
PMID: 27932946
The neuropeptide neurotensin (NT) elicits numerous pharmacological effects through three different receptors (NTSR1, NTSR2, and NTSR3 also called sortilin). Pharmacological approaches and generation of NTSR1 and NTSR2-deficient mice allowed to...
8.
Devader C, Roulot M, Moreno S, Minelli A, Bortolomasi M, Congiu C, et al.
J Affect Disord
. 2016 Nov;
208:443-447.
PMID: 27838145
Background: Despite intense research on mechanisms underlying the depressive pathophysiology, reliable biomarkers to assess antidepressant treatment response are still lacking. Since the sortilin-derived propeptide (PE) displays potent antidepressant activities and...
9.
Veyssiere J, Moha Ou Maati H, Mazella J, Gaudriault G, Moreno S, Heurteaux C, et al.
Psychopharmacology (Berl)
. 2014 Aug;
232(3):561-74.
PMID: 25080852
Rationale: Although depression is the most common mood disorder, only one third of patients are treated with success. Finding new targets, new drugs, and also new drug intake way are...
10.
Oules B, Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, et al.
J Neurosci
. 2012 Aug;
32(34):11820-34.
PMID: 22915123
In Alzheimer disease (AD), the perturbation of the endoplasmic reticulum (ER) calcium (Ca²⁺) homeostasis has been linked to presenilins, the catalytic core in γ-secretase complexes cleaving the amyloid precursor protein...