Paula A Pousinha
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Explore the profile of Paula A Pousinha including associated specialties, affiliations and a list of published articles.
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18
Citations
553
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Recent Articles
1.
Dunot J, Moreno S, Gandin C, Pousinha P, Amici M, Dupuis J, et al.
Neuron
. 2024 Jun;
112(16):2708-2720.e9.
PMID: 38878768
NMDA receptors (NMDARs) are ionotropic receptors crucial for brain information processing. Yet, evidence also supports an ion-flux-independent signaling mode mediating synaptic long-term depression (LTD) and spine shrinkage. Here, we identify...
2.
Dunot J, Ribera A, Pousinha P, Marie H
Curr Opin Neurobiol
. 2023 Aug;
82:102754.
PMID: 37542943
The amyloid-β precursor protein (APP) is a ubiquitous protein with a strong genetic link to Alzheimer's disease. Although the protein was identified more than forty years ago, its physiological function...
3.
Rajao-Saraiva J, Dunot J, Ribera A, Temido-Ferreira M, Coelho J, Konig S, et al.
Aging Cell
. 2023 Jan;
22(3):e13778.
PMID: 36704841
N-methyl-D-aspartate receptors (NMDARs) are critical for the maturation and plasticity of glutamatergic synapses. In the hippocampus, NMDARs mainly contain GluN2A and/or GluN2B regulatory subunits. The amyloid precursor protein (APP) has...
4.
Bianchi D, Migliore R, Vitale P, Garad M, Pousinha P, Marie H, et al.
Biophys J
. 2022 Jan;
121(4):644-657.
PMID: 34999132
In this work, we highlight an electrophysiological feature often observed in recordings from mouse CA1 pyramidal cells that has so far been ignored by experimentalists and modelers. It consists of...
5.
Brigas H, Ribeiro M, Coelho J, Gomes R, Gomez-Murcia V, Carvalho K, et al.
Cell Rep
. 2021 Sep;
36(9):109574.
PMID: 34469732
Neuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has been recognized for decades, but the contribution of the recently described meningeal immune population to AD pathogenesis remains...
6.
Mensch M, Dunot J, Yishan S, Harris S, Blistein A, Avdiu A, et al.
Alzheimers Res Ther
. 2021 Jul;
13(1):125.
PMID: 34238366
Background: Amyloid precursor protein (APP) processing is central to Alzheimer's disease (AD) etiology. As early cognitive alterations in AD are strongly correlated to abnormal information processing due to increasing synaptic...
7.
Ribeiro M, Brigas H, Temido-Ferreira M, Pousinha P, Regen T, Santa C, et al.
Sci Immunol
. 2019 Oct;
4(40).
PMID: 31604844
The notion of "immune privilege" of the brain has been revised to accommodate its infiltration, at steady state, by immune cells that participate in normal neurophysiology. However, the immune mechanisms...
8.
Pousinha P, Mouska X, Bianchi D, Temido-Ferreira M, Rajao-Saraiva J, Gomes R, et al.
Cell Rep
. 2019 Oct;
29(2):317-331.e5.
PMID: 31597094
There is a growing consensus that Alzheimer's disease (AD) involves failure of the homeostatic machinery, which underlies the firing stability of neural circuits. What are the culprits leading to neuron...
9.
Temido-Ferreira M, Coelho J, Pousinha P, Lopes L
J Caffeine Adenosine Res
. 2019 Sep;
9(3):104-127.
PMID: 31559391
While neuronal loss has long been considered as the main contributor to age-related cognitive decline, these alterations are currently attributed to gradual synaptic dysfunction driven by calcium dyshomeostasis and alterations...
10.
Salgueiro-Pereira A, Duprat F, Pousinha P, Loucif A, Douchamps V, Regondi C, et al.
Neurobiol Dis
. 2019 Jan;
125:31-44.
PMID: 30659983
SCN1A (Na1.1 sodium channel) mutations cause Dravet syndrome (DS) and GEFS+ (which is in general milder), and are risk factors in other epilepsies. Phenotypic variability limits precision medicine in epilepsy,...