Sebastien Lemieux
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Explore the profile of Sebastien Lemieux including associated specialties, affiliations and a list of published articles.
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81
Citations
3606
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Recent Articles
1.
Bordeleau M, Audemard E, Metois A, Theret L, Lisi V, Farah A, et al.
Cell Rep
. 2024 Jun;
43(6):114260.
PMID: 38838225
Immunotherapy remains underexploited in acute myeloid leukemia (AML) compared to other hematological malignancies. Currently, gemtuzumab ozogamicin is the only therapeutic antibody approved for this disease. Here, to identify potential targets...
2.
Larouche J, Laumont C, Trofimov A, Vincent K, Hesnard L, Brochu S, et al.
Elife
. 2024 Apr;
12.
PMID: 38635416
Transposable elements (TEs) are repetitive sequences representing ~45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTECs). In this study, we investigated the...
3.
Scicluna M, Grenier J, Poujol R, Lemieux S, Hussin J
Bioinform Adv
. 2023 Sep;
3(1):vbad097.
PMID: 37720006
Summary: We describe the problem of computing local feature attributions for dimensionality reduction methods. We use one such method that is well established within the context of supervised classification-using the...
4.
Ruiz Cuevas M, Hardy M, Larouche J, Apavaloaei A, Kina E, Vincent K, et al.
Genome Biol
. 2023 Aug;
24(1):188.
PMID: 37582761
MHC-I-associated peptides deriving from non-coding genomic regions and mutations can generate tumor-specific antigens, including neoantigens. Quantifying tumor-specific antigens' RNA expression in malignant and benign tissues is critical for discriminating actionable...
5.
Trofimov A, Brouillard P, Larouche J, Seguin J, Laverdure J, Brasey A, et al.
iScience
. 2022 Sep;
25(9):104968.
PMID: 36111255
Based on analyses of TCR sequences from over 1,000 individuals, we report that the TCR repertoire is composed of two ontogenically and functionally distinct types of TCRs. Their production is...
6.
Wu Z, Bonneil E, Belford M, Boeser C, Ruiz Cuevas M, Lemieux S, et al.
Anal Chem
. 2022 Aug;
94(35):12086-12094.
PMID: 35995421
The sensitivity and depth of proteomic analyses are limited by isobaric ions and interferences that preclude the identification of low abundance peptides. Extensive sample fractionation is often required to extend...
7.
Apavaloaei A, Hesnard L, Hardy M, Benabdallah B, Ehx G, Theriault C, et al.
Cell Rep
. 2022 Aug;
40(7):111241.
PMID: 35977509
Previous reports showed that mouse vaccination with pluripotent stem cells (PSCs) induces durable anti-tumor immune responses via T cell recognition of some elusive oncofetal epitopes. We characterize the MHC I-associated...
8.
Lisi V, Blanchard E, Vladovsky M, Audemard E, Feghaly A, Lemieux S, et al.
Blood Adv
. 2022 Jul;
6(17):5160-5164.
PMID: 35849707
No abstract available.
9.
Veiga D, Tremblay M, Gerby B, Herblot S, Haman A, Gendron P, et al.
Front Immunol
. 2022 Apr;
13:867443.
PMID: 35401501
Early T-cell development is precisely controlled by E proteins, that indistinguishably include HEB/TCF12 and E2A/TCF3 transcription factors, together with NOTCH1 and pre-T cell receptor (TCR) signalling. Importantly, perturbations of early...
10.
Lang M, Lemieux S, Hebert J, Sauvageau G, Zawati M
J Med Internet Res
. 2021 Nov;
23(11):e26450.
PMID: 34762055
Background: This study aims to identify a novel potential use for web portals in health care and health research: their adoption for the purposes of rapidly sharing health research findings...