Sebastien Harlepp
Overview
Explore the profile of Sebastien Harlepp including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
795
Followers
0
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Recent Articles
1.
Ramirez M, Bou-Gharios J, Freis B, Draussin J, Cheignon C, Charbonniere L, et al.
Nanoscale
. 2025 Feb;
17(9):5021-5032.
PMID: 39903198
Developing and synthesizing nano-objects capable of enabling early targeted diagnosis and ensuring effective tumor treatment represents a significant challenge in the theranostic field. Among various nanoparticles (NPs), iron oxide nanoparticles...
2.
Freis B, Kiefer C, Ramirez M, Harlepp S, Mertz D, Pichon B, et al.
Nanoscale
. 2024 Oct;
16(44):20542-20555.
PMID: 39422589
Designing iron oxide nanoparticles (IONPs) to effectively combine magnetic hyperthermia (MH) and photothermia (PTT) in one IONP formulation presents a significant challenge to ensure a multimodal therapy allowing the adaptation...
3.
Jacquot G, Lopez Navarro P, Grange C, Boudali L, Harlepp S, Pivot X, et al.
Adv Mater
. 2024 Aug;
36(40):e2406604.
PMID: 39165046
In recent decades, subcutaneous (SC) administration of monoclonal antibodies (mAbs) has emerged as a promising alternative to intravenous delivery in oncology, offering comparable therapeutic efficacy while addressing patient preferences. This...
4.
Mathieu C, Ghosh S, Draussin J, Gasser A, Jacquot G, Banerjee M, et al.
Adv Healthc Mater
. 2024 Mar;
13(15):e2304250.
PMID: 38444191
Nanoparticle (NP) surface functionalization with proteins, including monoclonal antibodies (mAbs), mAb fragments, and various peptides, has emerged as a promising strategy to enhance tumor targeting specificity and immune cell interaction....
5.
Grea T, Jacquot G, Durand A, Mathieu C, Gasser A, Zhu C, et al.
Adv Mater
. 2023 Dec;
36(13):e2308738.
PMID: 38105299
Subcutaneous (SC) administration of monoclonal antibodies (mAbs) is a proven strategy for improving therapeutic outcomes and patient compliance. The current FDA-/EMA-approved enzymatic approach, utilizing recombinant human hyaluronidase (rHuPH20) to enhance...
6.
Freis B, Ramirez M, Kiefer C, Harlepp S, Iacovita C, Henoumont C, et al.
Pharmaceutics
. 2023 Apr;
15(4).
PMID: 37111590
Functionalized iron oxide nanoparticles (IONPs) are increasingly being designed as a theranostic nanoplatform combining specific targeting, diagnosis by magnetic resonance imaging (MRI), and multimodal therapy by hyperthermia. The effect of...
7.
Godeau A, Leoni M, Comelles J, Guyomar T, Lieb M, Delanoe-Ayari H, et al.
Elife
. 2022 Jul;
11.
PMID: 35899947
Directional cell locomotion requires symmetry breaking between the front and rear of the cell. In some cells, symmetry breaking manifests itself in a directional flow of actin from the front...
8.
Osmani N, Follain G, Gensbittel V, Garcia-Leon M, Harlepp S, Goetz J
Methods Mol Biol
. 2021 Mar;
2294:111-132.
PMID: 33742397
Cancer metastasis is a multistep process during which tumor cells leave the primary tumor mass and form distant secondary colonies that are lethal. Circulating tumor cells (CTCs) are transported by...
9.
Gensbittel V, Krater M, Harlepp S, Busnelli I, Guck J, Goetz J
Dev Cell
. 2020 Nov;
56(2):164-179.
PMID: 33238151
The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will successfully form life-threatening metastases when they undergo sequential steps along a journey from the primary tumor to...
10.
Follain G, Gensbittel V, Mary B, Lefebvre O, Harlepp S, Hyenne V, et al.
Med Sci (Paris)
. 2020 Oct;
36(10):872-878.
PMID: 33026329
Metastases are the main cause of cancer-related deaths. The chain of events leading to their development is called "the metastatic cascade". The biological and biochemical aspects of this process have...