Sebastien Granier
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Explore the profile of Sebastien Granier including associated specialties, affiliations and a list of published articles.
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45
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2712
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Recent Articles
1.
Perez Almeria C, Otun O, Schlimgen R, Lamme T, Crudden C, Youssef N, et al.
bioRxiv
. 2024 Nov;
PMID: 39574661
Chemokine stimulation of atypical chemokine receptor 3 (ACKR3) does not activate G proteins but recruits arrestins. It is a chemokine scavenger that indirectly influences responses by restricting the availability of...
2.
Fouillen A, Couvineau P, Gaibelet G, Riche S, Orcel H, Mendre C, et al.
Comput Struct Biotechnol J
. 2024 Nov;
23:3784-3799.
PMID: 39525085
G protein-coupled receptors (GPCRs) control critical cell signaling. Their response to extracellular stimuli involves conformational changes to convey signals to intracellular effectors, among which the most important are G proteins...
3.
Drakopoulos A, Koszegi Z, Seier K, Hubner H, Maurel D, Sounier R, et al.
J Med Chem
. 2024 Jul;
67(15):12618-12631.
PMID: 39044606
The delta opioid receptor (δOR or DOR) is a G protein-coupled receptor (GPCR) showing a promising profile as a drug target for nociception and analgesia. Herein, we design and synthesize...
4.
Otun O, Aljamous C, Del Nero E, Arimont-Segura M, Bosma R, Zarzycka B, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(30):e2404000121.
PMID: 39008676
Atypical Chemokine Receptor 3 (ACKR3) belongs to the G protein-coupled receptor family but it does not signal through G proteins. The structural properties that govern the functional selectivity and the...
5.
Bous J, Fouillen A, Orcel H, Granier S, Bron P, Mouillac B
Vitam Horm
. 2023 Sep;
123:67-107.
PMID: 37718002
Arginine-vasopressin (AVP) and oxytocin (OT) are neurohypophysial hormones which share a high sequence and structure homology. These are two cyclic C-terminally amidated nonapeptides with different residues at position 3 and...
6.
Healey R, Couillaud L, Hoh F, Mouhand A, Fouillen A, Couvineau P, et al.
Commun Chem
. 2023 Jul;
6(1):160.
PMID: 37507458
The polyhistidine (6XHis) motif is one of the most ubiquitous protein purification tags. The 6XHis motif enables the binding of tagged proteins to various metals, which can be advantageously used...
7.
Fouillen A, Bous J, Granier S, Mouillac B, Sounier R
Membranes (Basel)
. 2023 Jun;
13(6).
PMID: 37367810
G-protein coupled receptors (GPCRs) are versatile signaling proteins that regulate key physiological processes in response to a wide variety of extracellular stimuli. The last decade has seen a revolution in...
8.
Bous J, Fouillen A, Orcel H, Trapani S, Cong X, Fontanel S, et al.
Sci Adv
. 2022 Sep;
8(35):eabo7761.
PMID: 36054364
Arrestins interact with G protein-coupled receptors (GPCRs) to stop G protein activation and to initiate key signaling pathways. Recent structural studies shed light on the molecular mechanisms involved in GPCR-arrestin...
9.
Lambey P, Otun O, Cong X, Hoh F, Brunel L, Verdie P, et al.
Elife
. 2022 Mar;
11.
PMID: 35311641
(SA) leukocidin ED (LukED) belongs to a family of bicomponent pore forming toxins that play important roles in SA immune evasion and nutrient acquisition. LukED targets specific G protein-coupled chemokine...
10.
Healey R, Basu S, Humm A, Leyrat C, Cong X, Golebiowski J, et al.
Cell Rep Methods
. 2021 Nov;
1(6):None.
PMID: 34723237
Membrane proteins are central to many pathophysiological processes, yet remain very difficult to analyze structurally. Moreover, high-throughput structure-based drug discovery has not yet been exploited for membrane proteins because of...