Sebastian W Schultz
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Explore the profile of Sebastian W Schultz including associated specialties, affiliations and a list of published articles.
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21
Citations
1347
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Recent Articles
11.
Shoemaker C, Huang T, Weir N, Polyakov N, Schultz S, Denic V
PLoS Biol
. 2019 Apr;
17(4):e2007044.
PMID: 30933966
The power of forward genetics in yeast is the foundation on which the field of autophagy research firmly stands. Complementary work on autophagy in higher eukaryotes has revealed both the...
12.
Katheder N, Khezri R, OFarrell F, Schultz S, Jain A, Rahman M, et al.
Nature
. 2017 Jan;
541(7637):417-420.
PMID: 28077876
As malignant tumours develop, they interact intimately with their microenvironment and can activate autophagy, a catabolic process which provides nutrients during starvation. How tumours regulate autophagy in vivo and whether...
13.
Holland P, Knaevelsrud H, Soreng K, Mathai B, Lystad A, Pankiv S, et al.
Nat Commun
. 2016 Dec;
7:13889.
PMID: 28004827
A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome formation. HS1BP3 depletion increased the formation...
14.
Sanchez G, Alkhori L, Hatano E, Schultz S, Kuzhandaivel A, Jafari S, et al.
Cell Rep
. 2016 Jan;
14(3):464-470.
PMID: 26774485
Hedgehog (Hh) signaling is a key regulatory pathway during development and also has a functional role in mature neurons. Here, we show that Hh signaling regulates the odor response in...
15.
Driessen S, Berleth N, Friesen O, Loffler A, Bohler P, Hieke N, et al.
Autophagy
. 2015 Jul;
11(9):1458-70.
PMID: 26207339
Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The...
16.
Thorvaldsen T, Pedersen N, Wenzel E, Schultz S, Brech A, Liestol K, et al.
Mol Cancer Res
. 2015 Jul;
13(11):1487-501.
PMID: 26124443
Unlabelled: Tankyrase (TNKS) enzymes, due to their poly(ADP-ribose) polymerase activity, have emerged as potential targets in experimental cancer therapy. However, the functional consequences of TNKS inhibition remain incompletely resolved because...
17.
Vietri M, Schink K, Campsteijn C, Wegner C, Schultz S, Christ L, et al.
Nature
. 2015 Jun;
522(7555):231-5.
PMID: 26040712
At the onset of metazoan cell division the nuclear envelope breaks down to enable capture of chromosomes by the microtubule-containing spindle apparatus. During anaphase, when chromosomes have separated, the nuclear...
18.
Raiborg C, Wenzel E, Pedersen N, Olsvik H, Schink K, Schultz S, et al.
Nature
. 2015 Apr;
520(7546):234-8.
PMID: 25855459
The main organelles of the secretory and endocytic pathways--the endoplasmic reticulum (ER) and endosomes, respectively--are connected through contact sites whose numbers increase as endosomes mature. One function of such sites...
19.
Oskarsson M, Paulsson J, Schultz S, Ingelsson M, Westermark P, Westermark G
Am J Pathol
. 2015 Feb;
185(3):834-46.
PMID: 25700985
Several proteins have been identified as amyloid forming in humans, and independent of protein origin, the fibrils are morphologically similar. Therefore, there is a potential for structures with amyloid seeding...
20.
Kuzhandaivel A, Schultz S, Alkhori L, Alenius M
Cell Rep
. 2014 Apr;
7(3):672-80.
PMID: 24768000
Cilia mediate Hedgehog (Hh) signaling in vertebrates and Hh deregulation results in several clinical manifestations, such as obesity, cognitive disabilities, developmental malformations, and various cancers. Drosophila cells are nonciliated during...