Sebastian D Parlee
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Explore the profile of Sebastian D Parlee including associated specialties, affiliations and a list of published articles.
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23
Citations
1488
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Recent Articles
1.
Finan B, Parlee S, Yang B
Mol Metab
. 2020 Dec;
46:101153.
PMID: 33359400
Background: Non-alcoholic steatohepatitis (NASH) is a spectrum of histological liver pathologies ranging from hepatocyte fat accumulation, hepatocellular ballooning, lobular inflammation, and pericellular fibrosis. Based on early investigations, it was discovered...
2.
Optimization of Peptide Inhibitors of β-Klotho as Antagonists of Fibroblast Growth Factors 19 and 21
Pan J, Parlee S, Brunel F, Li P, Lu W, Perez-Tilve D, et al.
ACS Pharmacol Transl Sci
. 2020 Oct;
3(5):978-986.
PMID: 33073195
Fibroblast growth factors 19 and 21 (FGF19 and FGF21) have biological actions that render them promising clinical candidates for treatment of metabolic diseases, particularly dyslipidemia and nonalcoholic steatohepatitis (NASH). These...
3.
Alejandro E, Jo S, Akhaphong B, Romaguera Llacer P, Gianchandani M, Gregg B, et al.
Am J Physiol Regul Integr Comp Physiol
. 2020 Sep;
319(4):R485-R496.
PMID: 32877242
Maternal low-protein diet (LP) throughout gestation affects pancreatic β-cell fraction of the offspring at birth, thus increasing their susceptibility to metabolic dysfunction and type 2 diabetes in adulthood. The present...
4.
Scheller E, Khandaker S, Learman B, Cawthorn W, Anderson L, Pham H, et al.
Bone
. 2018 Jan;
118:32-41.
PMID: 29360620
Bone marrow adipose tissue (BMAT) is preserved or increased in states of caloric restriction. Similarly, we found that BMAT in the tail vertebrae, but not the red marrow in the...
5.
OBrien P, Hinder L, Parlee S, Hayes J, Backus C, Zhang H, et al.
Diabetes Obes Metab
. 2017 Mar;
19(10):1468-1472.
PMID: 28332276
Diabetic peripheral neuropathy (DPN) and diabetic kidney disease (DKD) are common diabetic complications with limited treatment options. Experimental studies show that targeting inflammation using chemokine receptor (CCR) antagonists ameliorates DKD,...
6.
Toulany J, Parlee S, Sinal C, Slayter K, McNeil S, Goralski K
Endocr Connect
. 2016 Nov;
5(6):70-81.
PMID: 27881447
Prochemerin is the inactive precursor of the adipokine chemerin. Proteolytic processing is obligatory for the conversion of prochemerin into active chemerin and subsequent regulation of cellular processes via the chemokine-like...
7.
Monitoring cell secretions on microfluidic chips using solid-phase extraction with mass spectrometry
Dugan C, Grinias J, Parlee S, El-Azzouny M, Evans C, Kennedy R
Anal Bioanal Chem
. 2016 Oct;
409(1):169-178.
PMID: 27761614
Microfluidics is an enabling technology for both cell biology and chemical analysis. We combine these attributes with a microfluidic device for on-line solid-phase extraction (SPE) and mass spectrometry (MS) analysis...
8.
Sulston R, Learman B, Zhang B, Scheller E, Parlee S, Simon B, et al.
Front Endocrinol (Lausanne)
. 2016 Oct;
7:128.
PMID: 27708617
Background: Bone marrow adipose tissue (MAT) contributes to increased circulating adiponectin, an insulin-sensitizing hormone, during caloric restriction (CR), but whether this occurs in other contexts remains unknown. The antidiabetic thiazolidinediones...
9.
Qiang G, Whang Kong H, Xu S, Pham H, Parlee S, Burr A, et al.
Mol Metab
. 2016 Jul;
5(7):480-490.
PMID: 27408774
Objective: Insulin signaling plays pivotal roles in the development and metabolism of many tissues and cell types. A previous study demonstrated that ablation of insulin receptor (IR) with aP2-Cre markedly...
10.
Cawthorn W, Scheller E, Parlee S, Pham H, Learman B, Redshaw C, et al.
Endocrinology
. 2015 Dec;
157(2):508-21.
PMID: 26696121
Bone marrow adipose tissue (MAT) accounts for up to 70% of bone marrow volume in healthy adults and increases further in clinical conditions of altered skeletal or metabolic function. Perhaps...