Sebastian Beck Jorgensen
Overview
Explore the profile of Sebastian Beck Jorgensen including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1068
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0
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Recent Articles
1.
Chan J, Tabatabaei Dakhili S, Lorenzana-Carrillo M, Gopal K, Pulente S, Greenwell A, et al.
Cell Rep
. 2024 Aug;
43(8):114573.
PMID: 39093701
Growth differentiation factor 15 (GDF15) is a peptide with utility in obesity, as it decreases appetite and promotes weight loss. Because obesity increases the risk for type 2 diabetes (T2D)...
2.
Sjoberg K, Sigvardsen C, Alvarado-Diaz A, Andersen N, Larance M, Seeley R, et al.
Cell Metab
. 2023 Jul;
35(8):1327-1340.e5.
PMID: 37473755
Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin action in obese rodents. Whether and how GDF15 improves insulin action without weight loss is unknown. Obese rats were...
3.
Wang D, Townsend L, DesOrmeaux G, Frangos S, Batchuluun B, Dumont L, et al.
Nature
. 2023 Jun;
619(7968):143-150.
PMID: 37380764
Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its effectiveness, in...
4.
Jorgensen S, Tang-Christensen M
Nat Metab
. 2022 Feb;
4(2):157-158.
PMID: 35177852
No abstract available.
5.
Wang D, Day E, Townsend L, Djordjevic D, Jorgensen S, Steinberg G
Nat Rev Endocrinol
. 2021 Aug;
17(10):592-607.
PMID: 34381196
Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily whose expression is increased in response to cellular stress and disease as well as by metformin. Elevations in...
6.
Martinussen C, Svane M, Bojsen-Moller K, Jensen C, Kristiansen V, Bookout A, et al.
Am J Physiol Endocrinol Metab
. 2021 Aug;
321(4):E443-E452.
PMID: 34370594
Growth differentiating factor 15 (GDF15) is expressed in the intestine and is one of the most recently identified satiety peptides. The mechanisms controlling its secretion are unclear. The present study...
7.
Cimino I, Kim H, Tung Y, Pedersen K, Rimmington D, Tadross J, et al.
Proc Natl Acad Sci U S A
. 2021 Jun;
118(27).
PMID: 34187898
An acute increase in the circulating concentration of glucocorticoid hormones is essential for the survival of severe somatic stresses. Circulating concentrations of GDF15, a hormone that acts in the brain...
8.
Sabatini P, Frikke-Schmidt H, Arthurs J, Gordian D, Patel A, Rupp A, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(8).
PMID: 33593916
The TGFβ cytokine family member, GDF-15, reduces food intake and body weight and represents a potential treatment for obesity. Because the brainstem-restricted expression pattern of its receptor, GDNF Family Receptor...
9.
Yang L, Chang C, Sun Z, Madsen D, Zhu H, Padkjaer S, et al.
Nat Med
. 2017 Aug;
23(10):1158-1166.
PMID: 28846099
Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. However, the cognate...
10.
Tsai V, Manandhar R, Jorgensen S, Lee-Ng K, Zhang H, Marquis C, et al.
PLoS One
. 2014 Jun;
9(6):e100370.
PMID: 24971956
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) modulates food intake and body weight under physiological and pathological conditions by acting on the hypothalamus and brainstem. When overexpressed in disease, such as in advanced...