Sean K Maynard
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Explore the profile of Sean K Maynard including associated specialties, affiliations and a list of published articles.
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10
Citations
170
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Recent Articles
1.
Rios K, Kashyap A, Maynard S, Washington M, Paul S, Schaefer B
Cell Immunol
. 2020 Aug;
356:104179.
PMID: 32763502
After T cell receptor (TCR) engagement, the CARD11-Bcl10-Malt1 (CBM) complex oligomerizes to transduce NF-κB activating signals. Bcl10 is then degraded to limit NF-κB activation. The cDNA AK057716 (BinCARD-1) was reported...
2.
Maynard S, Marshall J, MacGill R, Yu L, Cann J, Cheng L, et al.
BMC Cancer
. 2019 Jun;
19(1):540.
PMID: 31170937
Background: Despite considerable efforts at developing therapeutic vaccines for cancer, clinical translation of preclinical successes has been challenging, largely due to the difficulty of inducing strong and sustained cytotoxic T...
3.
Schneider-Ohrum K, Snell Bennett A, Rajani G, Hostetler L, Maynard S, Lazzaro M, et al.
J Virol
. 2019 May;
93(15).
PMID: 31092578
Respiratory syncytial virus (RSV) infection of seronegative children previously immunized with formalin-inactivated (FI) RSV has been associated with serious enhanced respiratory disease (ERD). The phenomenon was reproduced in the cotton...
4.
Cayatte C, Snell Bennett A, Rajani G, Hostetler L, Maynard S, Lazzaro M, et al.
PLoS One
. 2017 Nov;
12(11):e0188708.
PMID: 29182682
Respiratory syncytial virus (RSV) is recognized as an important cause of lower and upper respiratory tract infections in older adults, and a successful vaccine would substantially lower morbidity and mortality...
5.
Iyer V, Cayatte C, Marshall J, Sun J, Schneider-Ohrum K, Maynard S, et al.
J Pharm Sci
. 2017 Mar;
106(6):1490-1498.
PMID: 28259764
To generate potent vaccine responses, subunit protein antigens typically require coformulation with an adjuvant. Oil-in-water emulsions are among the most widely investigated adjuvants, based on their demonstrated ability to elicit...
6.
Lagraoui M, Sukumar G, Latoche J, Maynard S, Dalgard C, Schaefer B
Brain Behav Immun
. 2016 Dec;
61:96-109.
PMID: 27939247
Neuroinflammation plays a critical role in the pathogenesis of traumatic brain injury (TBI). TBI induces rapid activation of astrocytes and microglia, infiltration of peripheral leukocytes, and secretion of inflammatory cytokines....
7.
Marshall J, Heeke D, Rao E, Maynard S, Hornigold D, McCrae C, et al.
PLoS One
. 2016 Oct;
11(10):e0164632.
PMID: 27736941
The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chemically modified and detoxified variant, monophosphoryl lipid A (MPL). Although both molecules are active for human TLR4, they...
8.
Riner D, Ferragine C, Maynard S, Davies S
PLoS Pathog
. 2013 Oct;
9(10):e1003708.
PMID: 24130499
Blood flukes of the genus Schistosoma infect over 200 million people, causing granulomatous pathology with accompanying morbidity and mortality. As a consequence of extensive host-parasite co-evolution, schistosomes exhibit a complex...
9.
Kingeter L, Paul S, Maynard S, Cartwright N, Schaefer B
J Immunol
. 2010 Sep;
185(8):4520-4.
PMID: 20855880
TCR-mediated activation of the transcription factor NF-κB is required for T cell proliferation, survival, and effector differentiation. Although this pathway is the subject of intense study, it is not known...
10.
Lamb E, Walls C, Pesce J, Riner D, Maynard S, Crow E, et al.
PLoS Pathog
. 2010 May;
6(4):e1000892.
PMID: 20442785
Schistosoma blood flukes, which infect over 200 million people globally, co-opt CD4+ T cell-dependent mechanisms to facilitate parasite development and egg excretion. The latter requires Th2 responses, while the mechanism...