Sean J Whittaker
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Explore the profile of Sean J Whittaker including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1079
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Recent Articles
1.
Bakr F, Whittaker S
Front Oncol
. 2022 Dec;
12:1043254.
PMID: 36505788
Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of non-Hodgkin's lymphomas (NHL) characterised by the clonal proliferation of malignant, skin homing T-cells. Recent advances have been made in understanding the...
2.
Jones C, Degasperi A, Grandi V, Amarante T, Mitchell T, Nik-Zainal S, et al.
Sci Rep
. 2021 Feb;
11(1):3962.
PMID: 33597573
T-cell non-Hodgkin's lymphomas develop following transformation of tissue resident T-cells. We performed a meta-analysis of whole exome sequencing data from 403 patients with eight subtypes of T-cell non-Hodgkin's lymphoma to...
3.
Patel V, Flanagan C, Martins M, Jones C, Butler R, Woollard W, et al.
J Invest Dermatol
. 2019 Aug;
140(2):380-389.e4.
PMID: 31376383
Phospholipase C Gamma 1 (PLCG1) is frequently mutated in primary cutaneous T-cell lymphoma (CTCL). This study functionally interrogated nine PLCG1 mutations (p.R48W, p.S312L, p.D342N, p.S345F, p.S520F, p.R1158H, p.E1163K, p.D1165H, and...
4.
Butler R, McKenzie R, Jones C, Flanagan C, Woollard W, Demontis M, et al.
J Invest Dermatol
. 2019 Mar;
139(9):1975-1984.e2.
PMID: 30910759
FK228 (romidepsin) and suberoylanilide hydroxamic acid (vorinostat) are histone deacetylase inhibitors (HDACi) approved by the US Food and Drug Administration for cutaneous T-cell lymphoma (CTCL), including the leukemic subtype Sézary...
5.
Woollard W, Pullabhatla V, Lorenc A, Patel V, Butler R, Bayega A, et al.
Blood
. 2016 Apr;
127(26):3387-97.
PMID: 27121473
Sézary syndrome (SS) is a leukemic variant of cutaneous T-cell lymphoma (CTCL) and represents an ideal model for study of T-cell transformation. We describe whole-exome and single-nucleotide polymorphism array-based copy...
6.
Woollard W, Kalaivani N, Jones C, Roper C, Tung L, Lee J, et al.
J Invest Dermatol
. 2016 Feb;
136(6):1238-1246.
PMID: 26872600
Methylthioadenosine phosphorylase (MTAP) and the tumor suppressor genes CDKN2A-CDKN2B are frequently deleted in malignancies. The specific role of MTAP in cutaneous T-cell lymphoma subgroups, mycosis fungoides (MF) and Sézary syndrome...
7.
Scarisbrick J, Prince H, Vermeer M, Quaglino P, Horwitz S, Porcu P, et al.
J Clin Oncol
. 2015 Oct;
33(32):3766-73.
PMID: 26438120
Purpose: Advanced-stage mycosis fungoides (MF; stage IIB to IV) and Sézary syndrome (SS) are aggressive lymphomas with a median survival of 1 to 5 years. Clinical management is stage based;...
8.
Jones C, Ferreira S, McKenzie R, Tosi I, Caesar J, Bagot M, et al.
J Invest Dermatol
. 2012 Apr;
132(8):2042-9.
PMID: 22495182
T-plastin (PLS3) is an actin-bundling protein normally expressed in epithelial cells but absent in cells of hematopoietic origin. Aberrant PLS3 expression has been demonstrated in lymphocytes from Sézary syndrome (SS)...
9.
Dummer R, Beyer M, Hymes K, Epping M, Bernards R, Steinhoff M, et al.
Leuk Lymphoma
. 2012 Jan;
53(8):1501-8.
PMID: 22239668
The retinoid X receptor (RXR)-agonist bexarotene and the histone deacetylase inhibitor (HDACI) vorinostat are each established monotherapies for cutaneous T-cell lymphomas (CTCLs). We investigated the combination of HDACI and retinoic...
10.
Agar N, Wedgeworth E, Crichton S, Mitchell T, Cox M, Ferreira S, et al.
J Clin Oncol
. 2010 Sep;
28(31):4730-9.
PMID: 20855822
Purpose: We have analyzed the outcome of mycosis fungoides (MF) and Sézary syndrome (SS) patients using the recent International Society for Cutaneous Lymphomas (ISCL)/European Organisation for Research and Treatment of...