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Sean Escopete

Explore the profile of Sean Escopete including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Ariyasinghe N, Gupta D, Escopete S, Rai D, Stotland A, Sundararaman N, et al.
Int J Mol Sci . 2025 Jan; 26(1. PMID: 39796045
The prevalence of cardiovascular disease varies with sex, and the impact of intrinsic sex-based differences on vasculature is not well understood. Animal models can provide important insights into some aspects...
2.
Mozneb M, Moses J, Arzt M, Escopete S, Sharma A
Curr Protoc . 2024 Oct; 4(10):e70030. PMID: 39446337
Calcium plays a pivotal role in the excitation-contraction coupling process in cardiomyocytes, a critical multi-parametric event leading to rhythmic contraction. Over the past few decades, calcium signaling in cardiomyocytes has...
3.
Khalil N, Rexius-Hall M, Escopete S, Parker S, McCain M
J Mol Cell Cardiol Plus . 2024 Sep; 9. PMID: 39329164
Myocardial infarction (MI) causes hypoxic injury to downstream myocardial tissue, which initiates a wound healing response that replaces injured myocardial tissue with a scar. Wound healing is a complex process...
4.
Ariyasinghe N, Gupta D, Escopete S, Stotland A, Sundararaman N, Ngu B, et al.
bioRxiv . 2024 Aug; PMID: 39211096
Significance: In this work, we have differentiated 4 male and 4 female iPSC lines into vascular smooth muscle cells, giving us the ability to identify statistically-significant sex-specific proteomic markers that...
5.
Arzt M, Mozneb M, Escopete S, Moses J, Sharma A
Stem Cells Dev . 2024 Feb; 33(5-6):143-147. PMID: 38326760
Over the past 15 years, there has been a significant shift in biomedical research toward a major focus on stem cell research. Although stem cells and their derivatives exhibit potential...
6.
Saddic L, Escopete S, Zilberberg L, Kalsow S, Gupta D, Eghbali M, et al.
Int J Mol Sci . 2023 Sep; 24(17). PMID: 37686377
Marfan syndrome causes a hereditary form of thoracic aortic aneurysms with worse outcomes in male compared to female patients. In this study, we examine the effects of 17 β-estradiol on...
7.
Ariyasinghe N, de Souza Santos R, Gross A, Aghamaleky-Sarvestany A, Kreimer S, Escopete S, et al.
Physiol Genomics . 2023 Jun; 55(8):324-337. PMID: 37306406
The vascular endothelium constitutes the inner lining of the blood vessel, and malfunction and injuries of the endothelium can cause cardiovascular diseases as well as other diseases including stroke, tumor...
8.
Saddic L, Escopete S, Zilberberg L, Kalsow S, Gupta D, Egbhali M, et al.
bioRxiv . 2023 May; PMID: 37215011
Marfan syndrome causes a hereditary form of thoracic aortic aneurysms with dilation of the aortic root. Human and animal models suggest a worse phenotype for males compared to females with...
9.
Sundararaman N, Bhat A, Venkatraman V, Binek A, Dwight Z, Ariyasinghe N, et al.
J Proteome Res . 2023 Jan; 22(2):471-481. PMID: 36695565
Recent surges in large-scale mass spectrometry (MS)-based proteomics studies demand a concurrent rise in methods to facilitate reliable and reproducible data analysis. Quantification of proteins in MS analysis can be...
10.
Perez-Marron J, Sanders C, Gomez E, Escopete S, Owerkowicz T, Orwin P
Comp Biochem Physiol A Mol Integr Physiol . 2022 Sep; 274:111319. PMID: 36115554
We report here the community structure and functional analysis of the microbiome of the Alligator mississippiensis GI tract from the oral cavity through the entirety of the digestive tract. Although...