Sean Eddy
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Explore the profile of Sean Eddy including associated specialties, affiliations and a list of published articles.
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40
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1287
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Recent Articles
1.
Eddy S, Nair V, Hartman J, Fermin D, Eichinger F, Godfrey B, et al.
medRxiv
. 2025 Mar;
PMID: 40061330
Translational Statement: Cross-species mapping of sparsentan response in rat and human studies identified similar networks which were elevated in a subset of people with more severe focal segmental glomerulosclerosis (FSGS)...
2.
Alakwaa F, Das V, Majumdar A, Nair V, Fermin D, Dey A, et al.
JCI Insight
. 2025 Mar;
10(5).
PMID: 40059827
Chronic kidney diseases (CKDs) are a global health concern, necessitating a comprehensive understanding of their complex pathophysiology. This study explores the use of 2 complementary multidimensional -omics data integration methods...
3.
Trachtman H, Modi Z, Ju W, Lee E, Chinnakotla S, Massengill S, et al.
Kidney360
. 2025 Jan;
6(2):284-295.
PMID: 39808779
No abstract available.
4.
Tisch A, Madapoosi S, Blough S, Rosa J, Eddy S, Mariani L, et al.
Heliyon
. 2024 Oct;
10(19):e38567.
PMID: 39403515
Introduction: Single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA sequencing (snRNA-seq) provide valuable insights into the cellular states of kidney cells. However, the annotation of cell types often requires extensive domain...
5.
Troost J, DSouza J, Buxton M, Kshirsagar A, Engel L, OLenick C, et al.
Kidney Int Rep
. 2024 Aug;
9(8):2527-2536.
PMID: 39156153
Introduction: Environmental contributors to kidney disease progression remain elusive. We explored how residential air pollution affects disease progression in patients with primary glomerulopathies. Methods: Nephrotic Syndrome Study Network (NEPTUNE) and...
6.
Yoon J, Liu Z, Alaba M, Bruggeman L, Janmey P, Arana C, et al.
bioRxiv
. 2024 Jul;
PMID: 38948788
Objectives: To understand the early stages if Alport nephropathy, we characterize the structural, functional, and biophysical properties of glomerular capillaries and podocytes in mice, analyze kidney cortex transcriptional profiles at...
7.
Juliar B, Stanaway I, Sano F, Fu H, Smith K, Akilesh S, et al.
Cell Rep
. 2024 Jun;
43(6):114310.
PMID: 38838223
Elevated interferon (IFN) signaling is associated with kidney diseases including COVID-19, HIV, and apolipoprotein-L1 (APOL1) nephropathy, but whether IFNs directly contribute to nephrotoxicity remains unclear. Using human kidney organoids, primary...
8.
Anandakrishnan N, Yi Z, Sun Z, Liu T, Haydak J, Eddy S, et al.
medRxiv
. 2024 Apr;
PMID: 38562892
COVID-19 has been a significant public health concern for the last four years; however, little is known about the mechanisms that lead to severe COVID-associated kidney injury. In this multicenter...
9.
Reznichenko A, Nair V, Eddy S, Fermin D, Tomilo M, Slidel T, et al.
Kidney Int
. 2024 Jan;
105(6):1263-1278.
PMID: 38286178
Current classification of chronic kidney disease (CKD) into stages using indirect systemic measures (estimated glomerular filtration rate (eGFR) and albuminuria) is agnostic to the heterogeneity of underlying molecular processes in...
10.
Cohen C, Mhaidly R, Croizer H, Kieffer Y, Leclere R, Vincent-Salomon A, et al.
Nat Commun
. 2024 Jan;
15(1):743.
PMID: 38272907
Chronic kidney disease (CKD) is a public health problem driven by myofibroblast accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized characteristic in kidney fibroblasts in CKD, but the...