Sean D McGrath
Overview
Explore the profile of Sean D McGrath including associated specialties, affiliations and a list of published articles.
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24
Citations
7231
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Recent Articles
11.
Wartman L, Larson D, Xiang Z, Ding L, Chen K, Lin L, et al.
J Clin Invest
. 2011 Mar;
121(4):1445-55.
PMID: 21436584
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). It is characterized by the t(15;17)(q22;q11.2) chromosomal translocation that creates the promyelocytic leukemia-retinoic acid receptor α (PML-RARA) fusion...
12.
Ley T, Ding L, Walter M, McLellan M, Lamprecht T, Larson D, et al.
N Engl J Med
. 2010 Nov;
363(25):2424-33.
PMID: 21067377
Background: The genetic alterations responsible for an adverse outcome in most patients with acute myeloid leukemia (AML) are unknown. Methods: Using massively parallel DNA sequencing, we identified a somatic mutation...
13.
Ding L, Ellis M, Li S, Larson D, Chen K, Wallis J, et al.
Nature
. 2010 Apr;
464(7291):999-1005.
PMID: 20393555
Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumour progression. Here we describe the genomic analyses of four DNA samples...
14.
Hughes J, Skaletsky H, Pyntikova T, Graves T, van Daalen S, Minx P, et al.
Nature
. 2010 Jan;
463(7280):536-9.
PMID: 20072128
The human Y chromosome began to evolve from an autosome hundreds of millions of years ago, acquiring a sex-determining function and undergoing a series of inversions that suppressed crossing over...
15.
Chen K, Wallis J, McLellan M, Larson D, Kalicki J, Pohl C, et al.
Nat Methods
. 2009 Aug;
6(9):677-81.
PMID: 19668202
Detection and characterization of genomic structural variation are important for understanding the landscape of genetic variation in human populations and in complex diseases such as cancer. Recent studies demonstrate the...
16.
Mardis E, Ding L, Dooling D, Larson D, McLellan M, Chen K, et al.
N Engl J Med
. 2009 Aug;
361(11):1058-66.
PMID: 19657110
Background: The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not yet known. Methods: We used massively parallel DNA sequencing to...
17.
Wang X, Sun Q, McGrath S, Mardis E, Soloway P, Clark A
PLoS One
. 2008 Dec;
3(12):e3839.
PMID: 19052635
Imprinted genes display differential allelic expression in a manner that depends on the sex of the transmitting parent. The degree of imprinting is often tissue-specific and/or developmental stage-specific, and may...
18.
Alekseyenko A, Peng S, Larschan E, Gorchakov A, Lee O, Kharchenko P, et al.
Cell
. 2008 Aug;
134(4):599-609.
PMID: 18724933
The Drosophila MSL complex associates with active genes specifically on the male X chromosome to acetylate histone H4 at lysine 16 and increase expression approximately 2-fold. To date, no DNA...
19.
Locke D, Sharp A, McCarroll S, McGrath S, Newman T, Cheng Z, et al.
Am J Hum Genet
. 2006 Jul;
79(2):275-90.
PMID: 16826518
Studies of copy-number variation and linkage disequilibrium (LD) have typically excluded complex regions of the genome that are rich in duplications and prone to rearrangement. In an attempt to assess...
20.
Perry G, Tchinda J, McGrath S, Zhang J, Picker S, Caceres A, et al.
Proc Natl Acad Sci U S A
. 2006 May;
103(21):8006-11.
PMID: 16702545
Copy number variation is surprisingly common among humans and can be involved in phenotypic diversity and variable susceptibility to complex diseases, but little is known of the extent of copy...