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Scott V Bratman

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Articles 136
Citations 7068
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Recent Articles
1.
Waas M, Karamboulas C, Wu B, Khan S, Poon S, Meens J, et al.
Nat Commun . 2024 Dec; 15(1):10869. PMID: 39738080
There is a pressing need to improve risk stratification and treatment selection for HPV-negative head and neck squamous cell carcinoma (HNSCC) due to the adverse side effects of treatment. One...
2.
Guan L, Torres-Saavedra P, Zhao X, Major M, Holmes B, Nguyen N, et al.
Clin Cancer Res . 2024 Dec; PMID: 39656603
Purpose: NFE2L2/KEAP1/CUL3 mutations have been validated for radiation resistance in cell-based assays and animal models. However, clinical validation of these biomarkers has been challenging due to multimodality treatment regimens. This...
3.
Barghout S, Meti N, Chotai S, Kim C, Patel D, Brown M, et al.
Br J Cancer . 2024 Nov; 132(2):139-153. PMID: 39572762
The field of precision oncology has witnessed several advances that stimulated the development of new clinical trial designs and the emergence of real-world data (RWD) as an important resource for...
4.
Haq S, Downs G, Zhan L, Schmid S, Patel D, Sacdalan D, et al.
JTO Clin Res Rep . 2024 Nov; 5(12):100702. PMID: 39564094
Introduction: SCLC has traditionally been considered to arise from toxic exposure factors, such as smoking. Recent evidence has revealed that germline mutations may also affect the development of SCLC; however,...
5.
Thakral A, Lee J, Hou T, Hueniken K, Dudding T, Gormley M, et al.
Nat Commun . 2024 Sep; 15(1):7835. PMID: 39244563
HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are recognized as distinct entities. There remains uncertainty surrounding the causal effects of smoking and alcohol on the development of...
6.
Hernando-Calvo A, Yang S, Vila-Casadesus M, Han M, Liu Z, Berman A, et al.
JCO Precis Oncol . 2024 Aug; 8:e2400100. PMID: 39178369
Purpose: Immune gene expression signatures are emerging as potential biomarkers for immunotherapy (IO). VIGex is a 12-gene expression classifier developed in both nCounter (Nanostring) and RNA sequencing (RNA-seq) assays and...
7.
Alsheikh S, Su J, OSullivan B, Ringash J, Waldron J, Bratman S, et al.
Oral Oncol . 2024 Aug; 158:107007. PMID: 39173454
Objectives: Clinical extranodal extension (cENE) is a cN modifier in TNM-8 for laryngo-hypopharygeal carcinoma (LHC). We hypothesize that image-detected ENE (iENE) can provide additional prognostic value over cENE in LHC....
8.
Oliva M, Heirali A, Watson G, Rooney A, Cochrane K, Jennings S, et al.
Br J Cancer . 2024 May; 130(12):1936-1942. PMID: 38714747
Background: Gut microbiome modulation to boost antitumor immune responses is under investigation. Methods: ROMA-2 evaluated the microbial ecosystem therapeutic (MET)-4 oral consortia, a mixture of cultured human stool-derived immune-responsiveness associated...
9.
de Almeida J, Martino R, Hosni A, Goldstein D, Bratman S, Chepeha D, et al.
JAMA Otolaryngol Head Neck Surg . 2024 Apr; 150(6):463-471. PMID: 38602692
Importance: Patients with unknown primary squamous cell carcinoma (CUP) with cervical metastases typically receive comprehensive radiotherapy (RT) of the pharynx and bilateral neck. Typically, these patients receive comprehensive RT of...
10.
Chepeha D, Barbon C, Esemezie A, Al Mardini M, Philteos J, Spector M, et al.
Head Neck . 2024 Apr; 46(7):1737-1751. PMID: 38561946
Background: To address the rehabilitative barriers to frequency and precision of care, we conducted a pilot study of a biofeedback electropalatography (EPG) device paired with telemedicine for patients who underwent...