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Scott R Penzak

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Articles 84
Citations 1657
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Penzak S, Bulloch M
J Clin Pharmacol . 2024 Feb; 64(6):652-671. PMID: 38339875
β-Phenyl-γ-aminobutyric acid (phenibut) is an analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that was first synthesized in Russia in the early 1960s. It is marketed as a nootropic (smart...
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Penzak S, Durham S, Phillippe H, Fox B
Pharmacy (Basel) . 2024 Jan; 12(1). PMID: 38251400
Kratom () is a botanical substance whose leaves produce stimulant- and opioid-like effects. Kratom use has increased precipitously in the United States (U.S.) over the last decade, yet, in our...
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Liyanage M, Blaquera C, Piscitelli J, Penzak S, Nolin T, Paine M, et al.
Int J Clin Pharmacol Ther . 2023 Apr; 61(6):262-269. PMID: 37042268
Objective: Fexofenadine is a probe drug used to phenotype P-glycoprotein (P-gp) and organic anion transporting polypeptide (OATP) 1B1/3 activities. This study evaluated a limited sampling strategy using plasma concentrations and/or...
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Piscitelli J, Nikanjam M, Capparelli E, Blaquera C, Penzak S, Nolin T, et al.
Ther Drug Monit . 2023 Jan; 45(4):539-545. PMID: 36645711
Background: Fexofenadine is a recommended in vivo probe drug for phenotyping P-glycoprotein (P-gp) and organic anion transporting polypeptide (OATP) 1B1/3 transporter activities. This study evaluated a limited sampling strategy using...
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Hartley 2nd C, Bulloch M, Penzak S
J Clin Pharmacol . 2021 Nov; 62(5):577-593. PMID: 34775626
Kratom (Mitragyna speciosa) consists of over 40 alkaloids, with 2 of them, mitragynine and 7-OH-mitragynine (7-OH-MG) being the main psychoactive compounds. Mitragynine and 7-OH-mitragynine each target opioid receptors and have...
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Yang J, Nikanjam M, Capparelli E, Tsunoda S, Greenberg H, Penzak S, et al.
J Clin Pharmacol . 2019 May; 59(11):1495-1504. PMID: 31051051
We have previously described a midazolam limited sampling strategy employing a population pharmacokinetic (PK) approach to estimate constitutive cytochrome P450 (CYP) 3A activity. This study evaluated expansion of this approach...
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Penzak S, Rojas-Fernandez C
J Clin Pharmacol . 2019 Feb; 59(5):611-624. PMID: 30748026
A number of cytochrome P450 (CYP)3A phenotyping probes have been used to characterize the drug interaction potential of new molecular entities; of these, midazolam has emerged as the gold standard....
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Pinelli N, Sease J, Nola K, Kyle J, Heldenbrand S, Penzak S, et al.
Am J Pharm Educ . 2018 Sep; 82(6):6694. PMID: 30181676
Academic pharmacy spans several generations including traditionalists, baby boomers, Generation X, and Generation Y, commonly referred to as millennials. It has been suggested that leadership styles must change to accommodate...
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Jann M, Penzak S
CNS Drugs . 2018 Jun; 32(6):603. PMID: 29858836
1. In Page 244, under General Pharmacokinetic Principles, Column 1-the following sentence should come after reference 21.