Alpha 2.0
Login Register
» Authors » Scott R Kronewitter

Scott R Kronewitter

Explore the profile of Scott R Kronewitter including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 18
Citations 647
Followers 0
Related Specialties
Chemistry
Biochemistry
General Medicine
Top 10 Co-Authors
Carlito B Lebrilla
Hyun Joo An
Richard D Smith
Suzanne Miyamoto
Gary S Leiserowitz
Ronald J Moore
Maria Lorna A De Leoz
James L Stephenson Jr
Ioan Marginean
Jason R Neil
Published In
Anal Chem
Proteomics
Bioinformatics
Curr Opin Chem Biol
Microb Biotechnol
Affiliations
Soon will be listed here.
Recent Articles
1.
Direct detection of OXA-48-like carbapenemase variants with and without co-expression of an extended-spectrum β-lactamase from bacterial cell lysates using mass spectrometry
McGee W, Verma A, Viirtola M, Kronewitter S, Neil J, Stephenson Jr J
J Mass Spectrom Adv Clin Lab . 2021 Nov; 20:25-34. PMID: 34820668
Introduction: Antibiotic-resistant Gram-negative bacteria are of a growing concern globally, especially those producing enzymes conferring resistance. OXA-48-like carbapenemases hydrolyze most β-lactam antibiotics, with typically low-level hydrolysis of carbapenems, but have...
2.
Direct detection of intact carbapenemase variants from cell lysates: Identification, characterization and clinical implications
McGee W, Faron M, Neil J, Kronewitter S, Buchan B, Ledeboer N, et al.
Clin Mass Spectrom . 2021 Nov; 17:12-21. PMID: 34820520
Introduction: Carbapenemase-producing organisms (CPOs) are a growing threat to human health. Among the enzymes conferring antibiotic resistance produced by these organisms, carbapenemase (KPC) is considered to be a growing global...
3.
Rapid MRSA detection via tandem mass spectrometry of the intact 80 kDa PBP2a resistance protein
Neil J, Verma A, Kronewitter S, McGee W, Mullen C, Viirtola M, et al.
Sci Rep . 2021 Sep; 11(1):18309. PMID: 34526615
Treatment of antibiotic-resistant infections is dependent on the detection of specific bacterial genes or proteins in clinical assays. Identification of methicillin-resistant Staphylococcus aureus (MRSA) is often accomplished through the detection...
4.
High sensitivity combined with extended structural coverage of labile compounds via nanoelectrospray ionization at subambient pressures
Cox J, Kronewitter S, Shukla A, Moore R, Smith R, Tang K
Anal Chem . 2014 Sep; 86(19):9504-11. PMID: 25222651
Subambient pressure ionization with nanoelectrospray (SPIN) has proven to be effective in producing ions with high efficiency and transmitting them to low pressures for increased sensitivity in mass spectrometry (MS)...
5.
Polysialylated N-glycans identified in human serum through combined developments in sample preparation, separations, and electrospray ionization-mass spectrometry
Kronewitter S, Marginean I, Cox J, Zhao R, Hagler C, Shukla A, et al.
Anal Chem . 2014 Aug; 86(17):8700-10. PMID: 25118826
The N-glycan diversity of human serum glycoproteins, i.e., the human blood serum N-glycome, is both complex and constrained by the range of glycan structures potentially synthesizable by human glycosylation enzymes....
6.
GlyQ-IQ: glycomics quintavariate-informed quantification with high-performance computing and GlycoGrid 4D visualization
Kronewitter S, Slysz G, Marginean I, Hagler C, LaMarche B, Zhao R, et al.
Anal Chem . 2014 Jun; 86(13):6268-76. PMID: 24881670
Glycomics quintavariate-informed quantification (GlyQ-IQ) is a biologically guided glycomics analysis tool for identifying N-glycans in liquid chromatography-mass spectrometry (LC-MS) data. Glycomics LC-MS data sets have convoluted extracted ion chromatograms that...
7.
A Multi-Omic View of Host-Pathogen-Commensal Interplay in Salmonella-Mediated Intestinal Infection
Deatherage Kaiser B, Li J, Sanford J, Kim Y, Kronewitter S, Jones M, et al.
PLoS One . 2013 Jul; 8(6):e67155. PMID: 23840608
The potential for commensal microorganisms indigenous to a host (the 'microbiome' or 'microbiota') to alter infection outcome by influencing host-pathogen interplay is largely unknown. We used a multi-omics "systems" approach,...
8.
Automated assignments of N- and O-site specific glycosylation with extensive glycan heterogeneity of glycoprotein mixtures
Strum J, Nwosu C, Hua S, Kronewitter S, Seipert R, Bachelor R, et al.
Anal Chem . 2013 May; 85(12):5666-75. PMID: 23662732
Site-specific glycosylation (SSG) of glycoproteins remains a considerable challenge and limits further progress in the areas of proteomics and glycomics. Effective methods require new approaches in sample preparation, detection, and...
9.
Improving N-glycan coverage using HPLC-MS with electrospray ionization at subambient pressure
Marginean I, Kronewitter S, Moore R, Slysz G, Monroe M, Anderson G, et al.
Anal Chem . 2012 Oct; 84(21):9208-13. PMID: 23025344
Human serum glycan profiling with mass spectrometry (MS) has been employed to study several disease conditions and is demonstrating promise in, for example, clinical biomarker discovery. However, the low glycan...
10.
The glycolyzer: automated glycan annotation software for high performance mass spectrometry and its application to ovarian cancer glycan biomarker discovery
Kronewitter S, De Leoz M, Strum J, An H, Dimapasoc L, Guerrero A, et al.
Proteomics . 2012 Aug; 12(15-16):2523-38. PMID: 22903841
Human serum glycomics is a promising method for finding cancer biomarkers but often lacks the tools for streamlined data analysis. The Glycolyzer software incorporates a suite of analytic tools capable...