Scott Maynard
Overview
Explore the profile of Scott Maynard including associated specialties, affiliations and a list of published articles.
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19
Citations
930
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Recent Articles
1.
Maynard S, Hall A, Galanos P, Rizza S, Yamamoto T, Gram H, et al.
Nucleic Acids Res
. 2022 Sep;
50(17):9948-9965.
PMID: 36099415
Mutations in the lamin A/C gene (LMNA) cause laminopathies such as the premature aging Hutchinson Gilford progeria syndrome (HGPS) and altered lamin A/C levels are found in diverse malignancies. The...
2.
Kosar M, Giannattasio M, Piccini D, Maya-Mendoza A, Garcia-Benitez F, Bartkova J, et al.
Nat Commun
. 2021 Jun;
12(1):3937.
PMID: 34168151
Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr depletion generates transcription-dependent replication stress, DNA breaks, and genomic instability. DNA...
3.
Maynard S, Keijzers G, Akbari M, Ben Ezra M, Hall A, Morevati M, et al.
Nucleic Acids Res
. 2019 Oct;
47(22):11709-11728.
PMID: 31647095
The A-type lamins (lamin A/C), encoded by the LMNA gene, are important structural components of the nuclear lamina. LMNA mutations lead to degenerative disorders known as laminopathies, including the premature...
4.
Hall A, Maynard S, Wu L, Merchut-Maya J, Strauss R, Moein Moghimi S, et al.
J Control Release
. 2019 Jul;
309:158-172.
PMID: 31348978
Acquired resistance to the oncogenic BRAF inhibitor vemurafenib is a major clinical challenge in the treatment of melanoma. Vemurafenib resistance is poorly understood; however, available evidence indicates that reprogrammed mitochondrial...
5.
Nygaard R, Maynard S, Schjerling P, Kjaer M, Qvortrup K, Bohr V, et al.
Case Rep Dermatol
. 2016 Jun;
8(1):42-51.
PMID: 27293393
Cutis laxa is a rare disease characterized by abnormal skin wrinkling and laxity, due to decreased elastin synthesis or structural extracellular matrix defects. We have explored elastin metabolism in a...
6.
Maynard S, Hejl A, Dinh T, Keijzers G, Hansen A, Desler C, et al.
Aging (Albany NY)
. 2015 Nov;
7(10):793-815.
PMID: 26539816
Aims: Accurate biomarkers for early diagnosis of Alzheimer's disease (AD) are badly needed. Recent reports suggest that dysfunctional mitochondria and DNA damage are associated with AD development. In this report,...
7.
Desler C, Frederiksen J, Angleys M, Maynard S, Keijzers G, Fagerlund B, et al.
Mitochondrion
. 2015 Sep;
25:34-7.
PMID: 26408413
Mitochondrial bioenergetics, mitochondrial reactive oxygen species (ROS) and cellular levels of nucleotides have been hypothesized as early indicators of Alzheimer's disease (AD). Utilizing relative decline of cognitive ability as a...
8.
Maynard S, Fang E, Scheibye-Knudsen M, Croteau D, Bohr V
Cold Spring Harb Perspect Med
. 2015 Sep;
5(10).
PMID: 26385091
Aging in mammals is accompanied by a progressive atrophy of tissues and organs, and stochastic damage accumulation to the macromolecules DNA, RNA, proteins, and lipids. The sequence of the human...
9.
Maynard S, Ghosh R, Wu Y, Yan S, Miyake T, Gagliardi M, et al.
J Cell Physiol
. 2014 Dec;
230(7):1475-88.
PMID: 25514832
Nutrient depletion triggers a series of adaptive processes as part of the unfolded protein response or UPR. These processes reduce stress to the endoplasmic reticulum by enhancing its protein folding...
10.
Keijzers G, Maynard S, Shamanna R, Rasmussen L, Croteau D, Bohr V
Crit Rev Biochem Mol Biol
. 2014 Jul;
49(6):463-72.
PMID: 25048400
DNA double-strand breaks are highly toxic DNA lesions that cause genomic instability, if not efficiently repaired. RecQ helicases are a family of highly conserved proteins that maintain genomic stability through...