Scott M Coyle
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Explore the profile of Scott M Coyle including associated specialties, affiliations and a list of published articles.
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17
Citations
1036
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Recent Articles
1.
Rajasekaran R, Galateo T, Xu Z, Bolshakov D, Weix E, Coyle S
bioRxiv
. 2025 Mar;
PMID: 40060462
Radios and cellphones use frequency modulation (FM) of an oscillating carrier signal to reliably transmit multiplexed data while rejecting noise. Here, we establish a biochemical analogue of this paradigm using...
2.
Chang C, Coyle S
J Biol Chem
. 2024 Jul;
300(8):107544.
PMID: 38992434
Microtubule filaments are assembled into higher-order structures using microtubule-associated proteins. However, synthetic MAPs that direct the formation of new structures are challenging to design, as nanoscale biochemical activities must be...
3.
Rajasekaran R, Chang C, Weix E, Galateo T, Coyle S
Cell
. 2024 Jan;
187(2):345-359.e16.
PMID: 38181787
Cells self-organize molecules in space and time to generate complex behaviors, but we lack synthetic strategies for engineering spatiotemporal signaling. We present a programmable reaction-diffusion platform for designing protein oscillations,...
4.
Chang C, Coyle S
bioRxiv
. 2023 Dec;
PMID: 38105997
Microtubules filaments are assembled into higher-order structures and machines critical for cellular processes using microtubule-associated proteins (MAPs). However, the design of synthetic MAPs that direct the formation of new structures...
5.
Ahn J, Coyle S
bioRxiv
. 2023 Nov;
PMID: 37961146
Cell dynamics are powered by patterns of activity, but it is not straightforward to quantify these patterns or compare them across different environmental conditions or cell-types. Here we digitize the...
6.
Coyle S
Mol Biol Cell
. 2020 Oct;
31(22):2415-2420.
PMID: 33054639
Place a drop of pond water under the microscope, and you will likely find an ocean of extraordinary and diverse single-celled organisms called . This remarkable group of single-celled organisms...
7.
Coyle S, Flaum E, Li H, Krishnamurthy D, Prakash M
Curr Biol
. 2019 Nov;
29(22):3838-3850.e3.
PMID: 31679941
Many single-celled protists use rapid morphology changes to perform fast animal-like behaviors. To understand how such behaviors are encoded, we analyzed the hunting dynamics of the predatory ciliate Lacrymaria olor,...
8.
Coyle S
Small GTPases
. 2016 Apr;
7(3):168-72.
PMID: 27128855
The Ras superfamily GTPases represent one of the most prolific signaling currencies used in Eukaryotes. With these remarkable molecules, evolution has built GTPase networks that control diverse cellular processes such...
9.
Morsut L, Roybal K, Xiong X, Gordley R, Coyle S, Thomson M, et al.
Cell
. 2016 Feb;
164(4):780-91.
PMID: 26830878
The Notch protein is one of the most mechanistically direct transmembrane receptors-the intracellular domain contains a transcriptional regulator that is released from the membrane when engagement of the cognate extracellular...
10.
Coyle S, Lim W
Elife
. 2016 Jan;
5.
PMID: 26765565
The Ras-superfamily GTPases are central controllers of cell proliferation and morphology. Ras signaling is mediated by a system of interacting molecules: upstream enzymes (GEF/GAP) regulate Ras's ability to recruit multiple...