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Scott Kennedy

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Articles 44
Citations 3102
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Recent Articles
1.
Lu P, Deng B, Li X, Niu X, Qiu Y, Liang Y, et al.
Nat Struct Mol Biol . 2025 Mar; PMID: 40082670
Biomolecular condensates, such as stress and germ granules, often contain subcompartments. For instance, the Caenorhabditis elegans germ granule, which localizes near the outer nuclear membrane of germ cell nuclei, is...
2.
Zhao L, Nardone C, Paulo J, Elledge S, Kennedy S
bioRxiv . 2025 Mar; PMID: 40027818
All genomes harbor mobile genetic parasites called transposable elements (TEs). Here we describe a system, which we term SOS splicing, that protects and human genes from DNA transposon-mediated disruption by...
3.
Zhao C, Cai S, Shi R, Li X, Deng B, Li R, et al.
Nat Cell Biol . 2024 Oct; 26(11):1958-1970. PMID: 39354132
Biomolecular condensates, such as the nucleolus, stress granules/processing bodies and germ granules, are multiphase assemblages whose formation mechanisms and significance remain poorly understood. Here we identify protein constituents of the...
4.
Chen X, Wang K, Mufti F, Xu D, Zhu C, Huang X, et al.
Nat Commun . 2024 Jul; 15(1):5799. PMID: 38987544
Germ granules are biomolecular condensates present in most animal germ cells. One function of germ granules is to help maintain germ cell totipotency by organizing mRNA regulatory machinery, including small...
5.
Xu H, Hon C, Kaiser S, Serrano-Fernandez P, Hartmann N, Yates D, et al.
Circ Genom Precis Med . 2021 Oct; 14(6):e003440. PMID: 34663088
No abstract available.
6.
Shukla A, Perales R, Kennedy S
Curr Biol . 2021 Aug; 31(20):4473-4485.e3. PMID: 34428467
Noncoding RNAs have emerged as mediators of transgenerational epigenetic inheritance (TEI) in a number of organisms. A robust example of such RNA-directed TEI is the inheritance of gene-silencing states following...
7.
Hartl D, De Luca V, Kostikova A, Laramie J, Kennedy S, Ferrero E, et al.
J Transl Med . 2021 Jun; 19(1):245. PMID: 34090480
In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product and business model innovation, fundamentally changing the traditional approach of...
8.
Shukla A, Yan J, Pagano D, Dodson A, Fei Y, Gorham J, et al.
Nature . 2021 Apr; 592(7856):E27. PMID: 33854240
No abstract available.
9.
Li X, Shougat M, Kennedy S, Fendley C, Dean R, Beal A, et al.
PLoS One . 2021 Mar; 16(3):e0249131. PMID: 33765073
Adaptive oscillators (AOs) are nonlinear oscillators with plastic states that encode information. Here, an analog implementation of a four-state adaptive oscillator, including design, fabrication, and verification through hardware measurement, is...
10.
Wan G, Bajaj L, Fields B, Dodson A, Pagano D, Fei Y, et al.
EMBO J . 2021 Jan; 40(3):e105612. PMID: 33438773
Germ granules are biomolecular condensates that form in germ cells of all/most animals, where they regulate mRNA expression to promote germ cell function and totipotency. In the adult Caenorhabditis elegans...