Scott C Schmidler
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Explore the profile of Scott C Schmidler including associated specialties, affiliations and a list of published articles.
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15
Citations
175
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Recent Articles
1.
Hughes R, Zhao S, Oas T, Schmidler S
Biophys J
. 2023 Dec;
123(3):317-333.
PMID: 38158653
Helix-coil models are routinely used to interpret circular dichroism data of helical peptides or predict the helicity of naturally-occurring and designed polypeptides. However, a helix-coil model contains significantly more information...
2.
Mathews J, Van Itallie E, Wiehe K, Schmidler S
bioRxiv
. 2023 Oct;
PMID: 37905016
A key challenge in B cell lineage-based vaccine design is understanding the of target neutralizing antibodies. We approach this problem through the use of detailed stochastic modeling of the somatic...
3.
Schmidler S, Hughes R, Oas T, Zhao S
bioRxiv
. 2023 Sep;
PMID: 37745350
Helix-coil models are routinely used to interpret CD data of helical peptides or predict the helicity of naturally-occurring and designed polypeptides. However, a helix-coil model contains significantly more information than...
4.
Tonner P, Darnell C, Bushell F, Lund P, Schmid A, Schmidler S
PLoS Comput Biol
. 2020 Oct;
16(10):e1008366.
PMID: 33104703
Substantive changes in gene expression, metabolism, and the proteome are manifested in overall changes in microbial population growth. Quantifying how microbes grow is therefore fundamental to areas such as genetics,...
5.
Darnell C, Tonner P, Gulli J, Schmidler S, Schmid A
mSystems
. 2017 Sep;
2(5).
PMID: 28951888
Gene regulatory networks (GRNs) are critical for dynamic transcriptional responses to environmental stress. However, the mechanisms by which GRN regulation adjusts physiology to enable stress survival remain unclear. Here we...
6.
Rodriguez A, Schmidler S
Ann Appl Stat
. 2016 Mar;
8(4):2068-2095.
PMID: 26925188
The analysis of the three-dimensional structure of proteins is an important topic in molecular biochemistry. Structure plays a critical role in defining the function of proteins and is more strongly...
7.
Estrada R, Tomasi C, Schmidler S, Farsiu S
IEEE Trans Pattern Anal Mach Intell
. 2015 Sep;
37(8):1688-701.
PMID: 26353004
Tree-like structures are fundamental in nature, and it is often useful to reconstruct the topology of a tree - what connects to what - from a two-dimensional image of it....
8.
Herman J, Challis C, Novak A, Hein J, Schmidler S
Mol Biol Evol
. 2014 Jun;
31(9):2251-66.
PMID: 24899668
For sequences that are highly divergent, there is often insufficient information to infer accurate alignments, and phylogenetic uncertainty may be high. One way to address this issue is to make...
9.
Daniels K, Tonthat N, McClure D, Chang Y, Liu X, Schumacher M, et al.
J Am Chem Soc
. 2013 Dec;
136(3):822-5.
PMID: 24364358
Coupled ligand binding and conformational change plays a central role in biological regulation. Ligands often regulate protein function by modulating conformational dynamics, yet the order in which binding and conformational...
10.
Challis C, Schmidler S
Mol Biol Evol
. 2012 Jun;
29(11):3575-87.
PMID: 22723302
We present a stochastic process model for the joint evolution of protein primary and tertiary structure, suitable for use in alignment and estimation of phylogeny. Indels arise from a classic...