Scott B Crown
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Explore the profile of Scott B Crown including associated specialties, affiliations and a list of published articles.
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23
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1214
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Recent Articles
1.
Queathem E, Stagg D, Nelson A, Chaves A, Crown S, Fulghum K, et al.
bioRxiv
. 2024 Oct;
PMID: 39464122
The progression of metabolic-dysfunction-associated steatotic liver disease (MASLD) to metabolic-dysfunction-associated steatohepatitis (MASH) involves complex alterations in both liver-autonomous and systemic metabolism that influence the liver's balance of fat accretion and...
2.
Williams A, Crown S, Lyons S, Koves T, Wilson R, Johnson J, et al.
Cell Metab
. 2024 Feb;
36(2):422-437.e8.
PMID: 38325337
Time-restricted feeding (TRF) has gained attention as a dietary regimen that promotes metabolic health. This study questioned if the health benefits of an intermittent TRF (iTRF) schedule require ketone flux...
3.
Koves T, Zhang G, Davidson M, Chaves A, Crown S, Johnson J, et al.
Cell Metab
. 2023 Apr;
35(6):1038-1056.e8.
PMID: 37060901
Even-chain acylcarnitine (AC) metabolites, most of which are generated as byproducts of incomplete fatty acid oxidation (FAO), are viewed as biomarkers of mitochondrial lipid stress attributable to one or more...
4.
Trub A, Wagner G, Anderson K, Crown S, Zhang G, Thompson J, et al.
Nat Commun
. 2022 May;
13(1):2542.
PMID: 35538051
Statins are a class of drug widely prescribed for the prevention of cardiovascular disease, with pleiotropic cellular effects. Statins inhibit HMG-CoA reductase (HMGCR), which converts the metabolite HMG-CoA into mevalonate....
5.
Wilson R, Lyons S, Koves T, Bryson V, Zhang H, Li T, et al.
Mol Metab
. 2022 Jan;
57:101429.
PMID: 34979330
Objective: Stromal interaction molecule 1 (STIM1) is a single-pass transmembrane endoplasmic/sarcoplasmic reticulum (E/SR) protein recognized for its role in a store operated Ca entry (SOCE), an ancient and ubiquitous signaling...
6.
Yoneshiro T, Kataoka N, Walejko J, Ikeda K, Brown Z, Yoneshiro M, et al.
Elife
. 2021 May;
10.
PMID: 33944778
Importing necessary metabolites into the mitochondrial matrix is a crucial step of fuel choice during stress adaptation. Branched chain-amino acids (BCAAs) are essential amino acids needed for anabolic processes, but...
7.
Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
Walejko J, Christopher B, Crown S, Zhang G, Pickar-Oliver A, Yoneshiro T, et al.
Nat Commun
. 2021 Mar;
12(1):1680.
PMID: 33723250
Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that the major metabolic fate of uniformly-C-labeled α-ketoisovalerate ([U-C]KIV) in...
8.
White P, Lapworth A, McGarrah R, Kwee L, Crown S, Ilkayeva O, et al.
Cell Rep
. 2020 Nov;
33(6):108375.
PMID: 33176135
Glycine levels are inversely associated with branched-chain amino acids (BCAAs) and cardiometabolic disease phenotypes, but biochemical mechanisms that explain these relationships remain uncharted. Metabolites and genes related to BCAA metabolism...
9.
Yurdagul Jr A, Subramanian M, Wang X, Crown S, Ilkayeva O, Darville L, et al.
Cell Metab
. 2020 Feb;
31(3):518-533.e10.
PMID: 32004476
Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here, we show that the process is...
10.
Williams A, Koves T, Davidson M, Crown S, Fisher-Wellman K, Torres M, et al.
Cell Metab
. 2019 Dec;
31(1):131-147.e11.
PMID: 31813822
This study sought to examine the functional significance of mitochondrial protein acetylation using a double knockout (DKO) mouse model harboring muscle-specific deficits in acetyl-CoA buffering and lysine deacetylation, due to...