Scott A Tibbetts
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Explore the profile of Scott A Tibbetts including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
1532
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Recent Articles
31.
Coleman C, McGraw J, Feldman E, Roth A, Keyes L, Grau K, et al.
PLoS Pathog
. 2014 Feb;
10(2):e1003916.
PMID: 24516386
Gammaherpesviruses such as Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV, HHV-8) establish lifelong latency in their hosts and are associated with the development of several types of malignancies, including...
32.
Paden C, Forrest J, Tibbetts S, Speck S
PLoS Pathog
. 2012 Sep;
8(9):e1002906.
PMID: 22969427
The Latency-Associated Nuclear Antigen (LANA), encoded by ORF73, is a conserved gene among the γ2-herpesviruses (rhadinoviruses). The Kaposi's Sarcoma-Associated Herpesvirus (KSHV) LANA is consistently expressed in KSHV-associated malignancies. In the...
33.
Coleman C, Nealy M, Tibbetts S
J Virol
. 2010 Oct;
84(24):13045-52.
PMID: 20926565
Gammaherpesviruses, including Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 [HHV-8]), Epstein-Barr virus (EBV), and murine gammaherpesvirus 68 (MHV68; also known as gammaherpesvirus 68 [γHV68] or murine herpesvirus...
34.
Dong X, Feng H, Sun Q, Li H, Wu T, Sun R, et al.
PLoS Pathog
. 2010 Aug;
6(7):e1001001.
PMID: 20686657
Upon viral infection, the mitochondrial antiviral signaling (MAVS)-IKKbeta pathway is activated to restrict viral replication. Manipulation of immune signaling events by pathogens has been an outstanding theme of host-pathogen interaction....
35.
Nealy M, Coleman C, Li H, Tibbetts S
J Virol
. 2010 May;
84(15):7523-34.
PMID: 20484501
An integral feature of gammaherpesvirus infections is the ability to establish lifelong latency in B cells. During latency, the viral genome is maintained as an extrachomosomal episome, with stable maintenance...
36.
Li H, Ikuta K, Sixbey J, Tibbetts S
J Virol
. 2008 Jun;
82(17):8500-8.
PMID: 18562537
Murine gammaherpesvirus 68 (gammaHV68 or MHV68) is genetically related to the human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), providing a useful system for in vivo studies of...
37.
Tibbetts S, Suarez F, Steed A, Simmons J, Virgin 4th H
Virology
. 2006 Jun;
353(1):210-9.
PMID: 16797052
Chronic gamma-herpesvirus infection is a dynamic process involving latent infection, reactivation from latency, and low level persistent replication. The gamma-herpesviruses maintain latent infection in restricted subsets of hematopoietic cells as...
38.
Braaten D, McClellan J, Messaoudi I, Tibbetts S, McClellan K, Nikolich-Zugich J, et al.
PLoS Pathog
. 2006 May;
2(5):e37.
PMID: 16733540
Control of virus infection is mediated in part by major histocompatibility complex (MHC) Class Ia presentation of viral peptides to conventional CD8 T cells. Although important, the absolute requirement for...
39.
Steed A, Barton E, Tibbetts S, Popkin D, Lutzke M, Rochford R, et al.
J Virol
. 2005 Dec;
80(1):192-200.
PMID: 16352543
Establishment of latent infection and reactivation from latency are critical aspects of herpesvirus infection and pathogenesis. Interfering with either of these steps in the herpesvirus life cycle may offer a...
40.
Tarakanova V, Suarez F, Tibbetts S, Jacoby M, Weck K, Hess J, et al.
J Virol
. 2005 Nov;
79(23):14668-79.
PMID: 16282467
Human gammaherpesvirus infections are associated with development of lymphoproliferative disease. Understanding of the mechanisms of gammaherpesvirus lymphomagenesis during chronic infection in a natural host has been limited by the exquisite...