Sayaka Nagata
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Explore the profile of Sayaka Nagata including associated specialties, affiliations and a list of published articles.
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63
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Recent Articles
1.
Mizuta E, Kitada K, Nagata S, Ogura S, Sakima A, Suzuki J, et al.
Hypertens Res
. 2025 Mar;
PMID: 40055494
This systematic review and meta-analysis included cluster randomized controlled trials that compared population-based sodium reduction interventions with usual care for blood pressure (BP) management. We searched PubMed, Cochrane Central Register...
2.
Takahashi J, Sugihara H, Kato S, Kawasaki S, Nagata S, Okamoto R, et al.
Cell Rep Methods
. 2024 Dec;
4(12):100930.
PMID: 39662475
Human intestinal organoids (HIOs) derived from human pluripotent stem cells (hPSCs) are promising resources for intestinal regenerative therapy as they recapitulate both endodermal and mesodermal components of the intestine. However,...
3.
Ida T, Tominaga H, Iwamoto E, Kurogi A, Okura A, Shimada K, et al.
Front Endocrinol (Lausanne)
. 2024 Jun;
15:1411483.
PMID: 38828411
Ghrelin is a peptide hormone with various important physiological functions. The unique feature of ghrelin is its serine 3 acyl-modification, which is essential for ghrelin activity. The major form of...
4.
Takahashi J, Sugihara H, Kato S, Nagata S, Okamoto R, Mizutani T
STAR Protoc
. 2023 Jun;
4(3):102374.
PMID: 37352105
Current techniques for producing induced-pluripotent-stem-cell-derived mid/hindgut spheroids have faced major hurdles in consistency and reproducibility. Here, we present a protocol that uses mid/hindgut cells to generate homogeneous spheroids that subsequently...
5.
Kawaguchi M, Kataoka H, Kiwaki T, Weiting L, Nagata S, Kitamura K, et al.
FEBS Open Bio
. 2023 Feb;
13(4):713-723.
PMID: 36799102
Adrenomedullin (AM) is a peptide with pleiotropic physiological functions that attenuates intestinal mucosal inflammation. However, the mechanism underpinning mucosal protection by AM is not fully understood, and its effect on...
6.
Watanabe S, Ogasawara N, Kobayashi S, Kirino S, Inoue M, Hiraguri Y, et al.
J Gastroenterol
. 2023 Feb;
58(4):379-393.
PMID: 36745238
Background: The organoids therapy for ulcerative colitis (UC) is under development. It is important to dissect how the engrafted epithelium can provide benefits for overcoming the vulnerability to inflammation. We...
7.
Takahashi J, Mizutani T, Sugihara H, Nagata S, Kato S, Hiraguri Y, et al.
Cell Rep Methods
. 2022 Dec;
2(11):100337.
PMID: 36452871
Human intestinal organoids (HIOs) derived from human pluripotent stem cells (hPSCs) hold great promise for translational medical applications. A common method to obtain HIOs has been to harvest floating hindgut...
8.
Kobayashi S, Ogasawara N, Watanabe S, Yoneyama Y, Kirino S, Hiraguri Y, et al.
Inflamm Regen
. 2022 Nov;
42(1):49.
PMID: 36443773
Background: The emerging concepts of fetal-like reprogramming following tissue injury have been well recognized as an important cue for resolving regenerative mechanisms of intestinal epithelium during inflammation. We previously revealed...
9.
Nagata S, Yamasaki M, Kuroishi N, Kitamura K
Biology (Basel)
. 2022 Sep;
11(7).
PMID: 36101452
(1) Background: Human adrenomedullin (hAM) is a hypotensive peptide hormone that exerts powerful anti-inflammatory effects. AM also had therapeutic effects in various animal experimental models of disease. However, treatment required...
10.
Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis
Tamura A, Ito G, Matsuda H, Nibe-Shirakihara Y, Hiraoka Y, Kitagawa S, et al.
Biochem Biophys Res Commun
. 2022 Sep;
628:147-154.
PMID: 36087511
Expression of mucin MUC2, a component of the colonic mucus layer, plays a crucial role in intestinal homeostasis. Here, we describe a new regulator of MUC2 expression, the deubiquitinase ZRANB1...