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Sayaka Nagata

Explore the profile of Sayaka Nagata including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
11.
Yonaha T, Maruta T, Otao G, Igarashi K, Nagata S, Yano T, et al.
Anaesthesiol Intensive Ther . 2022 Feb; 53(5):411-417. PMID: 35100799
Introduction: Information about biologically active adrenomedullin (mature AM), a potential new biomarker for sepsis and septic shock, is limited. Here, we investigated the value of mature AM for diagnosis and...
12.
Otao G, Maruta T, Yonaha T, Igarashi K, Nagata S, Kitamura K, et al.
J Clin Transl Res . 2021 Jun; 7(3):302-310. PMID: 34179545
Background And Aim: Adrenomedullin (AM), a vasodilatory peptide, is known for its pleiotropic actions. AM levels are increased under inflammatory conditions such as sepsis and can be useful as a...
13.
Kuroishi N, Nagata S, Akashi E, Ashizuka S, Kato J, Yamasaki M, et al.
J Biochem . 2021 May; 170(4):445-451. PMID: 33964134
Adrenomedullin is a biologically active peptide with multiple functions. Here, we have developed a novel human serum albumin-adrenomedullin (HSA-AM) conjugate, which was synthesized by the covalent attachment of a maleimide...
14.
Yazawa T, Sato T, Nemoto T, Nagata S, Imamichi Y, Kitano T, et al.
J Steroid Biochem Mol Biol . 2021 Feb; 210:105847. PMID: 33609691
Porcine steroid hormone profiles have some unique characteristics. We previously studied human and murine steroidogenesis using steroidogenic cells-derived from mesenchymal stem cells (MSCs). To investigate porcine steroidogenesis, we induced steroidogenic...
15.
Kuno R, Ito G, Kawamoto A, Hiraguri Y, Sugihara H, Takeoka S, et al.
Biochem Biophys Rep . 2021 Jan; 25:100906. PMID: 33490652
Notch signaling is activated in the intestinal epithelial cells (IECs) of patients with inflammatory bowel disease (IBD), and contributes to mucosal regeneration. Our previous study indicated that TNF-α and Notch...
16.
Tsuchiya M, Ito G, Hama M, Nagata S, Kawamoto A, Suzuki K, et al.
Biochem Biophys Res Commun . 2021 Jan; 542:40-47. PMID: 33486190
Inflammatory bowel disease (IBD) comprises two major subtypes, ulcerative colitis (UC) and Crohn's disease, which are multifactorial diseases that may develop due to genetic susceptibility, dysbiosis, or environmental factors. Environmental...
17.
Nagata S, Fukuda A, Kikuchi M, Sato Y, Nagatomo M, Aburaya J, et al.
Nephrology (Carlton) . 2020 Dec; 26(5):479-484. PMID: 33381907
We previously described the discovery of Big angiotensin-25 (Bang-25), an angiotensin-related peptide isolated from human urine. Bang-25 consists of the first 25 amino acids of the N-terminus of angiotensinogen (Aogen),...
18.
Akashi E, Nagata S, Yamasaki M, Kitamura K
Biol Pharm Bull . 2020 Nov; 43(11):1799-1803. PMID: 33132326
Adrenomedullin (AM) improves colitis in animal models and patients with inflammatory bowel disease. We have developed a PEGylated AM derivative (PEG-AM) for clinical application because AM has a short half-life...
19.
Nishimoto Y, Nagata S, Akashi E, Yamasaki M, Kitamura K
Biochem Biophys Res Commun . 2020 Aug; 529(3):778-783. PMID: 32736707
Human adrenomedullin (AM) functions as a circulating hormone and as a local paracrine mediator with multiple biological activities. We investigated the metabolism of AM by examining its fragmentation in human...
20.
Wang H, Varagic J, Nagata S, Kon N, Ahmad S, VonCannon J, et al.
Data Brief . 2020 Jun; 31:105744. PMID: 32490094
The data presented here are related to the research article entitled "Differential expression of the angiotensin-(1-12) [Ang-(1-12)]/chymase axis in human atrial tissue [1]. We have showed that chymase gene transcripts,...