Saurabh J Pradhan
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Explore the profile of Saurabh J Pradhan including associated specialties, affiliations and a list of published articles.
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20
Citations
279
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Recent Articles
1.
Iyer D, Khoei H, van der Weijden V, Kagawa H, Pradhan S, Novatchkova M, et al.
Cell
. 2024 Sep;
187(23):6566-6583.e22.
PMID: 39332412
Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the...
2.
Suresh V, Bhattacharya B, Tshuva R, Danan Gotthold M, Olender T, Bose M, et al.
Oxf Open Neurosci
. 2024 Apr;
3:kvae001.
PMID: 38595939
PRDM16 is a dynamic transcriptional regulator of various stem cell niches, including adipocytic, hematopoietic, cardiac progenitors, and neural stem cells. PRDM16 has been suggested to contribute to 1p36 deletion syndrome,...
3.
Suresh V, Bhattacharya B, Tshuva R, Danan Gotthold M, Olender T, Bose M, et al.
bioRxiv
. 2023 Aug;
PMID: 37609127
PRDM16 is a dynamic transcriptional regulator of various stem cell niches, including adipocytic, hematopoietic, cardiac progenitors, and neural stem cells. PRDM16 has been suggested to contribute to 1p36 deletion syndrome,...
4.
Suresh V, Muralidharan B, Pradhan S, Bose M, DSouza L, Parichha A, et al.
PLoS Genet
. 2023 Aug;
19(8):e1010874.
PMID: 37594984
In the mammalian cerebral cortex, the hippocampal primordium (Hcp) occupies a discrete position in the dorsal telencephalic neuroepithelium adjacent to the neocortical primordium (Ncp). We examined transcriptomic and chromatin-level features...
5.
Khan S, Pradhan S, Giraud G, Bleicher F, Paul R, Merabet S, et al.
J Mol Evol
. 2023 Jun;
91(5):616-627.
PMID: 37341745
Hox genes encode Homeodomain-containing transcription factors, which specify segmental identities along the anterior-posterior axis. Functional changes in Hox genes have been directly implicated in the evolution of body plans across...
6.
Seong J, Frias-Aldeguer J, Holzmann V, Kagawa H, Sestini G, Khoei H, et al.
Cell Stem Cell
. 2022 Jul;
29(7):1102-1118.e8.
PMID: 35803228
The embryo instructs the allocation of cell states to spatially regulate functions. In the blastocyst, patterning of trophoblast (TR) cells ensures successful implantation and placental development. Here, we defined an...
7.
Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis
Pradhan S, Reddy P, Smutny M, Sharma A, Sako K, Oak M, et al.
Nat Commun
. 2021 Oct;
12(1):6094.
PMID: 34667153
Zygotic genome activation (ZGA) initiates regionalized transcription underlying distinct cellular identities. ZGA is dependent upon dynamic chromatin architecture sculpted by conserved DNA-binding proteins. However, the direct mechanistic link between the...
8.
Reddy P, Pradhan S, Karmodiya K, Galande S
J Biosci
. 2020 Jan;
45.
PMID: 31965986
Multicellular organisms have evolved sophisticated mechanisms for responding to various developmental, environmental and physical stimuli by regulating transcription. The correlation of distribution of RNA Polymerase II (RNA Pol II) with...
9.
Reddy P, Gungi A, Ubhe S, Pradhan S, Kolte A, Galande S
Commun Biol
. 2019 Dec;
2:434.
PMID: 31799436
Wnt/β-catenin signalling has been shown to play a critical role during head organizer formation in . Here, we characterized the Wnt signalling regulatory network involved in formation of the head...
10.
Balyan R, Gund R, Chawla A, Khare S, Pradhan S, Rane S, et al.
Immunology
. 2018 Dec;
156(4):384-401.
PMID: 30556901
We have previously demonstrated co-receptor level-associated functional heterogeneity in apparently homogeneous naive peripheral CD4 T cells, dependent on MHC-mediated tonic signals. Maturation pathways can differ between naive CD4 and naive...