Ashwin S Shetty
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Explore the profile of Ashwin S Shetty including associated specialties, affiliations and a list of published articles.
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16
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748
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Recent Articles
1.
Yuan W, Ma S, Brown J, Kim K, Murek V, Trastulla L, et al.
Nat Neurosci
. 2022 Aug;
25(8):1049-1058.
PMID: 35915179
Mammalian neocortical neurons span one of the most diverse cell type spectra of any tissue. Cortical neurons are born during embryonic development, and their maturation extends into postnatal life. The...
2.
Matho K, Huilgol D, Galbavy W, He M, Kim G, An X, et al.
Nature
. 2021 Oct;
598(7879):182-187.
PMID: 34616069
Diverse types of glutamatergic pyramidal neurons mediate the myriad processing streams and output channels of the cerebral cortex, yet all derive from neural progenitors of the embryonic dorsal telencephalon. Here...
3.
Jin X, Simmons S, Guo A, Shetty A, Ko M, Nguyen L, et al.
Science
. 2020 Nov;
370(6520).
PMID: 33243861
The number of disease risk genes and loci identified through human genetic studies far outstrips the capacity to systematically study their functions. We applied a scalable genetic screening approach, in...
4.
Chizhikov V, Iskusnykh I, Steshina E, Fattakhov N, Lindgren A, Shetty A, et al.
Nat Commun
. 2019 Nov;
10(1):5192.
PMID: 31729356
The extent of neocortical gyrification is an important determinant of a species' cognitive abilities, yet the mechanisms regulating cortical gyrification are poorly understood. We uncover long-range regulation of this process...
5.
Kinare V, Shetty A, Suresh A, Tole S
J Biosci
. 2018 Feb;
43(1):75-83.
PMID: 29485116
In the developing central nervous system, transcription factors play a crucial role in the regulation of cell fate. Previously we demonstrated that LHX2 is a critical regulator of the neuron-glia...
6.
Godbole G, Shetty A, Roy A, DSouza L, Chen B, Miyoshi G, et al.
Development
. 2017 Dec;
145(1).
PMID: 29229772
During forebrain development, a telencephalic organizer called the cortical hem is crucial for inducing hippocampal fate in adjacent cortical neuroepithelium. How the hem is restricted to its medial position is...
7.
Godbole G, Roy A, Shetty A, Tole S
Neural Dev
. 2017 Nov;
12(1):19.
PMID: 29141678
Patterning of the telencephalic neuroepithelium is a tightly regulated process controlled by transcription factors and signalling molecules. The cortical primordium is flanked by two signalling centres, the hem medially, and...
8.
Muralidharan B, Keruzore M, Pradhan S, Roy B, Shetty A, Kinare V, et al.
J Neurosci
. 2017 Oct;
37(46):11245-11254.
PMID: 29025924
Regulation of the neuron-glia cell-fate switch is a critical step in the development of the CNS. Previously, we demonstrated that Lhx2 is a necessary and sufficient regulator of this process...
9.
Kim J, Hughes E, Shetty A, Arlotta P, Goff L, Bergles D, et al.
J Neurosci
. 2017 Aug;
37(37):9037-9053.
PMID: 28821643
Cell type-specific changes in neuronal excitability have been proposed to contribute to the selective degeneration of corticospinal neurons in amyotrophic lateral sclerosis (ALS) and to neocortical hyperexcitability, a prominent feature...
10.
Platt R, Zhou Y, Slaymaker I, Shetty A, Weisbach N, Kim J, et al.
Cell Rep
. 2017 Apr;
19(2):335-350.
PMID: 28402856
Autism spectrum disorder (ASD) is a heterogeneous disease, but genetically defined models can provide an entry point to studying the molecular underpinnings of this disorder. We generated germline mutant mice...