Saul Kivimae
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Explore the profile of Saul Kivimae including associated specialties, affiliations and a list of published articles.
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19
Citations
786
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Recent Articles
11.
Kaasik K, Kivimae S, Allen J, Chalkley R, Huang Y, Baer K, et al.
Cell Metab
. 2013 Feb;
17(2):291-302.
PMID: 23395175
Posttranslational modifications play central roles in myriad biological pathways including circadian regulation. We employed a circadian proteomic approach to demonstrate that circadian timing of phosphorylation is a critical factor in...
12.
Kivimae S, Yang X, Cheyette B
BMC Biochem
. 2011 Jul;
12:33.
PMID: 21718540
Background: The Dact family of scaffold proteins was discovered by virtue of binding to Dvl proteins central to Wnt and Planar Cell Polarity (PCP) signaling. Subsequently Dact proteins have been...
13.
Okerlund N, Kivimae S, Tong C, Peng I, Ullian E, Cheyette B
J Neurosci
. 2010 Mar;
30(12):4362-8.
PMID: 20335472
Dact1 (Dapper/Frodo), an intracellular phosphoprotein that binds Dishevelled, catenins, and other signaling proteins, is expressed in the developing and mature mammalian CNS, but its function there is unknown. Dact1 colocalized...
14.
Kettunen P, Kivimae S, Keshari P, Klein O, Cheyette B, Luukko K
Gene Expr Patterns
. 2010 Feb;
10(2-3):140-3.
PMID: 20170752
Wnt signaling is essential for tooth formation and Dact proteins modulate Wnt signaling by binding to the intracellular protein Dishevelled (Dvl). Comparison of the three known mouse Dact genes, Dact1-3,...
15.
Suriben R, Kivimae S, Fisher D, Moon R, Cheyette B
Nat Genet
. 2009 Aug;
41(9):977-85.
PMID: 19701191
Mice homozygous for mutations in Dact1 (also called Dapper or Frodo) phenocopy human malformations involving the spine, genitourinary system and distal digestive tract. We traced this phenotype to disrupted germ-layer...
16.
Kivimae S, Saez L, Young M
PLoS Biol
. 2008 Aug;
6(7):e183.
PMID: 18666831
Protein phosphorylation plays an essential role in the generation of circadian rhythms, regulating the stability, activity, and subcellular localization of certain proteins that constitute the biological clock. This study examines...
17.
Jiang X, Tan J, Li J, Kivimae S, Yang X, Zhuang L, et al.
Cancer Cell
. 2008 Jun;
13(6):529-41.
PMID: 18538736
Genetic and epigenetic defects in Wnt/beta-catenin signaling play important roles in colorectal cancer progression. Here we identify DACT3, a member of the DACT (Dpr/Frodo) gene family, as a negative regulator...
18.
Fisher D, Kivimae S, Hoshino J, Suriben R, Martin P, Baxter N, et al.
Dev Dyn
. 2006 Aug;
235(9):2620-30.
PMID: 16881060
Members of the Dact protein family initially were identified through binding to Dishevelled (Dvl), a cytoplasmic protein central to Wnt signaling. During mouse development, Dact1 is detected in the presomitic...
19.
Harms E, Kivimae S, Young M, Saez L
J Biol Rhythms
. 2004 Nov;
19(5):361-73.
PMID: 15534317
Circadian rhythms have been observed in diverse organisms, including plants, animals, bacteria, and fungi. In such organisms, the circadian clock is primarily composed of a cell-autonomous transcriptional feedback loop. In...