Sathapana Kongsamut
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Explore the profile of Sathapana Kongsamut including associated specialties, affiliations and a list of published articles.
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9
Citations
147
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Recent Articles
1.
Kongsamut S, Eishingdrelo H
Drug Discov Today
. 2023 May;
28(8):103641.
PMID: 37236523
The activation of G-protein-coupled receptors (GPCRs) triggers a series of protein-protein interaction events that subsequently induce a chain of reactions, including alteration of receptor structures, phosphorylation, recruitment of associated proteins,...
2.
Eishingdrelo H, Qin X, Yuan L, Kongsamut S, Yu L
Curr Res Pharmacol Drug Discov
. 2022 Aug;
3:100123.
PMID: 35992381
GPCR signaling and function depend on their associated proteins and subcellular locations. Besides G-proteins and β-arrestins, 14-3-3 proteins participate in GPCR trafficking and signaling, and they connect a large number...
3.
Yuan L, Barbash S, Kongsamut S, Eishingdrelo A, Sakmar T, Eishingdrelo H
Sci Rep
. 2019 Aug;
9(1):11156.
PMID: 31371790
Receptor trafficking is pivotal for the temporal and spatial control of GPCR signaling and is regulated by multiple cellular proteins. We provide evidence that GPCRs interact with 14-3-3 signal adaptor/scaffold...
4.
Li H, Eishingdrelo A, Kongsamut S, Eishingdrelo H
Signal Transduct Target Ther
. 2017 Dec;
1:16018.
PMID: 29263900
G-protein-coupled receptor (GPCR)-interacting proteins likely participate in regulating GPCR signaling by eliciting specific signal transduction cascades, inducing cross-talk with other pathways, and fine tuning the signal. However, except for G-proteins...
5.
Griebel G, Pichat P, Boulay D, Naimoli V, Potestio L, Featherstone R, et al.
Sci Rep
. 2016 Oct;
6:35320.
PMID: 27734956
Normalization of altered glutamate neurotransmission through activation of the mGluR2 has emerged as a new approach to treat schizophrenia. These studies describe a potent brain penetrant mGluR2 positive allosteric modulator...
6.
Liang G, Chen X, Aldous S, Pu S, Mehdi S, Powers E, et al.
ACS Med Chem Lett
. 2014 Jun;
3(2):159-64.
PMID: 24900446
A series of compounds with an amidinothiophene P1 group and a pyrrolidinone-sulphonamide scaffold linker was identified as potent inhibitors of human kallikrein 6 by structure-based virtual screening based on the...
7.
Eishingdrelo H, Kongsamut S
Curr Chem Genom Transl Med
. 2014 Jan;
7:9-15.
PMID: 24396730
It has become clear in recent years that multiple signal transduction pathways are employed upon GPCR activation. One of the major cellular effectors activated by GPCRs is extracellular signal-regulated kinase...
8.
Smith C, Kongsamut S, Wang H, Ji J, Kang J, Rampe D
Clin Exp Pharmacol Physiol
. 2009 May;
36(11):1104-9.
PMID: 19413590
Summary 1. The non-selective K(+) channel blocker 4-aminopyridine (4-AP) has shown clinical efficacy in the treatment of neurological disorders such as multiple sclerosis. The clinical usefulness of 4-AP is hampered...
9.
A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs
Kongsamut S, Kang J, Chen X, Roehr J, Rampe D
Eur J Pharmacol
. 2002 Aug;
450(1):37-41.
PMID: 12176106
Many antipsychotic drugs produce QT interval prolongation on the electrocardiogram (ECG). Blockade of the human cardiac K(+) channel known as human ether-a-go-go-related gene (HERG) often underlies such clinical findings. In...