Sascha Keller
Overview
Explore the profile of Sascha Keller including associated specialties, affiliations and a list of published articles.
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38
Citations
2693
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Recent Articles
1.
Keller S, Kunz U, Schmid U, Beusmans J, Buchert M, He M, et al.
J Transl Med
. 2024 Oct;
22(1):934.
PMID: 39402675
Background: BI 836880 is a humanized bispecific nanobody® that binds to and blocks vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2). A comprehensive biomarker and modeling approach is presented here...
2.
Summer R, Todd J, Neely M, Lobo L, Namen A, Newby L, et al.
Respir Res
. 2024 Jan;
25(1):58.
PMID: 38273290
Background: The circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with idiopathic pulmonary fibrosis (IPF). We evaluated whether circulating levels of metabolites...
3.
Desch M, Schlecker C, Hohl K, Liesenfeld K, Chan T, Muller F, et al.
J Clin Psychopharmacol
. 2023 Jan;
43(2):113-121.
PMID: 36700734
Purpose/background: Glycine transporter-1 inhibitors may ameliorate cognitive deficits in schizophrenia. This study evaluated potential drug-drug interactions with the glycine transporter-1 inhibitor BI 425809. Methods/procedures: Interactions with cytochromes P450 (CYP) and...
4.
Muller F, Hohl K, Keller S, Schmidt-Gerets S, Deutsch B, Schuler-Metz A, et al.
Clin Pharmacol Ther
. 2023 Jan;
113(5):1070-1079.
PMID: 36636898
N -methylnicotinamide (NMN) has been proposed as endogenous biomarker for drug-drug interactions mediated by inhibition of multidrug and toxin extrusion proteins (MATEs) at the renal proximal tubule. We analyzed NMN...
5.
Koda K, Keller S, Kojima R, Kamiya M, Urano Y
Anal Chem
. 2022 Aug;
94(32):11264-11271.
PMID: 35913787
Acidification of intracellular vesicles, such as endosomes and lysosomes, is a key pathway for regulating the function of internal proteins. Most conventional methods of measuring pH are not satisfactory for...
6.
Desch M, Wunderlich G, Goettel M, Goetz S, Liesenfeld K, Chan T, et al.
Eur J Drug Metab Pharmacokinet
. 2021 Oct;
47(1):91-103.
PMID: 34716565
Background And Objective: Increased glycine availability at the synaptic cleft may enhance N-methyl-D-aspartate receptor signalling and provide a promising therapeutic strategy for cognitive impairment associated with schizophrenia. These studies aimed...
7.
Milaneschi Y, Allers K, Beekman A, Giltay E, Keller S, Schoevers R, et al.
Brain Behav Immun
. 2021 Jul;
97:167-175.
PMID: 34252568
Background: Tryptophan catabolites ("TRYCATs") produced by the kynurenine pathway (KP) may play a role in depression pathophysiology. Studies comparing TRYCATs levels in depressed subjects and controls provided mixed findings. We...
8.
Broermann A, Schmid R, Gabrielyan O, Sakowski M, Eisele C, Keller S, et al.
Int J Mol Sci
. 2021 Jan;
22(1).
PMID: 33396535
MicroRNAs (miRNAs) are short, non-coding RNA species that are important post-transcriptional regulators of gene expression and play an important role in the pathogenesis of non-alcoholic fatty liver disease. Here, we...
9.
Schneider M, Bracher T, Breitbach D, Lauer V, Pirro P, Bozhko D, et al.
Nat Nanotechnol
. 2020 Apr;
15(6):457-461.
PMID: 32313217
The fundamental phenomenon of Bose-Einstein condensation has been observed in different systems of real particles and quasiparticles. The condensation of real particles is achieved through a major reduction in temperature,...
10.
Nenno D, Scheuer L, Sokoluk D, Keller S, Torosyan G, Brodyanski A, et al.
Sci Rep
. 2019 Sep;
9(1):13348.
PMID: 31527771
Spintronic ferromagnetic/non-magnetic heterostructures are novel sources for the generation of THz radiation based on spin-to-charge conversion in the layers. The key technological and scientific challenge of THz spintronic emitters is...