Sasa Svikovic
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Explore the profile of Sasa Svikovic including associated specialties, affiliations and a list of published articles.
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11
Citations
349
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Recent Articles
1.
Mellor C, Nassar J, Svikovic S, Sale J
Nucleic Acids Res
. 2023 Nov;
52(1):243-258.
PMID: 37971291
The primase/polymerase PRIMPOL restarts DNA synthesis when replication is arrested by template impediments. However, we do not have a comprehensive view of how PRIMPOL-dependent repriming integrates with the main pathways...
2.
Wimberger S, Akrap N, Firth M, Brengdahl J, Engberg S, Schwinn M, et al.
Nat Commun
. 2023 Aug;
14(1):4761.
PMID: 37580318
Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration and generation of unintended mutations...
3.
Peterka M, Akrap N, Li S, Wimberger S, Hsieh P, Degtev D, et al.
Nat Commun
. 2022 Mar;
13(1):1240.
PMID: 35332138
Prime editing recently emerged as a next-generation approach for precise genome editing. Here we exploit DNA double-strand break (DSB) repair to develop two strategies that install precise genomic insertions using...
4.
Baxter C, Svikovic S, Sale J, Dean C, Costa S
Proc Natl Acad Sci U S A
. 2021 Jul;
118(28).
PMID: 34260408
How noncoding transcription influences chromatin states is still unclear. The floral repressor gene is quantitatively regulated through an antisense-mediated chromatin silencing mechanism. The antisense transcripts form a cotranscriptional R-loop that...
5.
Lerner L, Holzer S, Kilkenny M, Svikovic S, Murat P, Schiavone D, et al.
EMBO J
. 2020 Jul;
39(18):e104185.
PMID: 32705708
Regions of the genome with the potential to form secondary DNA structures pose a frequent and significant impediment to DNA replication and must be actively managed in order to preserve...
6.
Quinet A, Tirman S, Jackson J, Svikovic S, Lemacon D, Carvajal-Maldonado D, et al.
Mol Cell
. 2019 Nov;
77(3):461-474.e9.
PMID: 31676232
Acute treatment with replication-stalling chemotherapeutics causes reversal of replication forks. BRCA proteins protect reversed forks from nucleolytic degradation, and their loss leads to chemosensitivity. Here, we show that fork degradation...
7.
Svikovic S, Crisp A, Tan-Wong S, Guilliam T, Doherty A, Proudfoot N, et al.
EMBO J
. 2018 Nov;
38(3).
PMID: 30478192
During DNA replication, conflicts with ongoing transcription are frequent and require careful management to avoid genetic instability. R-loops, three-stranded nucleic acid structures comprising a DNA:RNA hybrid and displaced single-stranded DNA,...
8.
Karanovic J, Ivkovic M, Jovanovic V, Svikovic S, Pantovic-Stefanovic M, Brkusanin M, et al.
J Neural Transm (Vienna)
. 2017 Jan;
124(5):621-629.
PMID: 28084537
Suicidal behavior has been associated with a deficient serotonin neurotransmission which is likely a consequence of individual genetic architecture, exposure to environmental factors and interactions of those factors. We examined...
9.
Svikovic S, Sale J
J Mol Biol
. 2016 Nov;
429(13):2011-2029.
PMID: 27876548
When a cell divides, it must not only accurately duplicate its genome but also recapitulate its programme of gene expression. A significant body of evidence suggests that an important fraction...
10.
Karanovic J, Svikovic S, Pantovic M, Durica S, Brajuskovic G, Damjanovic A, et al.
World J Biol Psychiatry
. 2015 Mar;
16(4):261-71.
PMID: 25732952
Objectives: Adenosine to inosine RNA editing, serotonin 2C receptor (HTR2C), and stressful life events (SLEs) have all been implicated in suicidal behaviour. We examined the main and moderating effects of...