Saroj Kumar Rout
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Explore the profile of Saroj Kumar Rout including associated specialties, affiliations and a list of published articles.
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15
Citations
61
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Recent Articles
1.
Parua P, Ghosh S, Jana K, Seth A, Debnath B, Kumar Rout S, et al.
Curr Pharm Des
. 2024 Nov;
PMID: 39543801
Background: The COVID-19 pandemic has spurred significant endeavors to devise treatments to combat SARS-CoV-2. A limited array of small-molecule antiviral drugs, specifically monoclonal antibodies and interferon therapy, have been sanctioned...
2.
Rai V, Pradhan D, Halder J, Rajwar T, Mahanty R, Saha I, et al.
AAPS PharmSciTech
. 2024 Aug;
25(7):189.
PMID: 39160328
The intricate process of protein binding orchestrates crucial drug interactions within the bloodstream, facilitating the formation of soluble complexes. This research endeavours to improve the dissolution and oral bioavailability of...
3.
Kumar Rout S, Kastrati A, Jangra H, Schwarzer K, Sunagatullina A, Garny M, et al.
Chemistry
. 2022 Apr;
28(33):e202200733.
PMID: 35384103
DFT-calculations allow prediction of the reactivity of uncommon N-heterocyclic scaffolds of pyrazolo[1,5-a]pyrimidines and imidazo[1,2-b]pyridazines and considerably facilitate their functionalization. The derivatization of these N-heterocycles was realized using Grignard reagents for...
4.
Kumar Rout S, Marghem G, Lan J, Leyssens T, Riant O
Chem Commun (Camb)
. 2019 Nov;
55(99):14976-14979.
PMID: 31776530
Bicyclo[1.1.1]pentane (BCP) replacement as a bioisostere in drug molecules has an influence on their permeability, aqueous solubility and in vitro metabolic stability. Thus, the chemical installation of the BCP unit...
5.
Gogoi A, Guin S, Rajamanickam S, Kumar Rout S, Patel B
J Org Chem
. 2015 Sep;
80(18):9016-27.
PMID: 26332253
The higher propensity of C-N over C-S bond forming ability was demonstrated, through formal C-H functionalization during the construction of 4,5-disubstituted 1,2,4-triazole-3-thiones from arylidenearylthiosemicarbazides catalyzed by Cu(II). However, steric factors...
6.
Gogoi A, Modi A, Guin S, Kumar Rout S, Das D, Patel B
Chem Commun (Camb)
. 2014 Jul;
50(72):10445-7.
PMID: 25061987
A metal free synthesis of 3-aroylindole involving two sp(3) C-H activation has been achieved starting from o-alkynyl-N,N-dialkylamines using catalyst TBAI and oxidant TBHP.
7.
Kumar Rout S, Guin S, Ali W, Gogoi A, Patel B
Org Lett
. 2014 May;
16(11):3086-9.
PMID: 24852383
A copper-catalyzed cross-dehydrogenative coupling strategy has been developed for the synthesis of two classes of esters from simple solvents. The reaction of methylarenes with cyclic ethers resulted in α-acyloxy ethers...
8.
Kumar Rout S, Guin S, Gogoi A, Majji G, Patel B
Org Lett
. 2014 Mar;
16(6):1614-7.
PMID: 24588713
A variety of styrenes and phenylacetylenes serve as excellent arylcarboxy sources in bringing about substrate directed o-benzoxylation of 2-phenylpyridine derivatives catalyzed by Cu(II) in the presence of TBHP. This reaction...
9.
Kumar Rout S, Guin S, Banerjee A, Khatun N, Gogoi A, Patel B
Org Lett
. 2013 Aug;
15(16):4106-9.
PMID: 23924444
By using alkylbenzenes as aroyl surrogates, copper(II) catalyzed chemoselective O-aroylations of 1,3-dicarbonyl compounds and phenolic -OH ortho to carbonyl (-CHO, -COR) groups have been achieved. A dual mechanism operating in...
10.
Gogoi A, Guin S, Kumar Rout S, Patel B
Org Lett
. 2013 Apr;
15(8):1802-5.
PMID: 23541283
An efficient Cu(I)-catalyzed synthesis of 3-aroylindoles has been achieved from o-alkynylated N,N-dimethylamines via a sp(3) C-H bond activation α to the nitrogen atom followed by an intramolecular nucleophilic attack with...