Sarkis K Mazmanian
Overview
Explore the profile of Sarkis K Mazmanian including associated specialties, affiliations and a list of published articles.
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97
Citations
26131
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Recent Articles
1.
Morais L, Boktor J, Mahmoudiandehkordi S, Kaddurah-Daouk R, Mazmanian S
NPJ Parkinsons Dis
. 2024 Oct;
10(1):208.
PMID: 39477976
Pathological forms of α-synuclein contribute to synucleinopathies, including Parkinson's disease (PD). Most cases of PD arise from gene-environment interactions. Microbiome composition is altered in PD, and gut bacteria are causal...
2.
Morais L, Boktor J, Mahmoudiandehkordi S, Kaddurah-Daouk R, Mazmanian S
bioRxiv
. 2024 Jun;
PMID: 38915679
Pathological forms of the protein α-synuclein contribute to a family of disorders termed synucleinopathies, which includes Parkinson's disease (PD). Most cases of PD are believed to arise from gene-environment interactions....
3.
Bostick J, Connerly T, Thron T, Needham B, de Castro Fonseca M, Kaddurah-Daouk R, et al.
bioRxiv
. 2024 May;
PMID: 38766238
: Preclinical studies reveal that the microbiome broadly affects immune responses and deposition and/or clearance of amyloid-beta (Aβ) in mouse models of Alzheimer's disease (AD). Whether the microbiome shapes central...
4.
Griffiths J, Yoo B, Thuy-Boun P, Cantu V, Weldon K, Challis C, et al.
Cell Rep
. 2024 Mar;
43(4):113953.
PMID: 38517896
The gastrointestinal (GI) tract is innervated by intrinsic neurons of the enteric nervous system (ENS) and extrinsic neurons of the central nervous system and peripheral ganglia. The GI tract also...
5.
Nemet I, Funabashi M, Li X, Dwidar M, Sangwan N, Skye S, et al.
mBio
. 2023 Nov;
14(6):e0133123.
PMID: 37947418
Alterations in gut microbial composition and function have been linked to numerous diseases. Identifying microbial pathways responsible for producing molecules that adversely impact the host is an important first step...
6.
Abdel-Haq R, Schlachetzki J, Boktor J, Cantu-Jungles T, Thron T, Zhang M, et al.
Elife
. 2023 Aug;
12.
PMID: 37650862
No abstract available.
7.
Morton J, Jin D, Mills R, Shao Y, Rahman G, McDonald D, et al.
Nat Neurosci
. 2023 Jun;
26(7):1208-1217.
PMID: 37365313
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut-brain axis (GBA) has been implicated in ASD although with limited...
8.
Boktor J, Sharon G, Verhagen Metman L, Hall D, Engen P, Zreloff Z, et al.
Mov Disord
. 2023 Jan;
38(3):399-409.
PMID: 36691982
Background: The gut microbiome is altered in several neurologic disorders, including Parkinson's disease (PD). Objectives: The aim is to profile the fecal gut metagenome in PD for alterations in microbial...
9.
Ousey J, Boktor J, Mazmanian S
Curr Biol
. 2022 Nov;
33(1):147-157.e7.
PMID: 36450285
Feeding behaviors depend on intrinsic and extrinsic factors including genetics, food palatability, and the environment. The gut microbiota is a major environmental contributor to host physiology and impacts feeding behavior....
10.
Abdel-Haq R, Schlachetzki J, Boktor J, Cantu-Jungles T, Thron T, Zhang M, et al.
Elife
. 2022 Nov;
11.
PMID: 36346385
Parkinson's disease (PD) is a movement disorder characterized by neuroinflammation, α-synuclein pathology, and neurodegeneration. Most cases of PD are non-hereditary, suggesting a strong role for environmental factors, and it has...