S Melanie Lee
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Explore the profile of S Melanie Lee including associated specialties, affiliations and a list of published articles.
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12
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2705
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Recent Articles
1.
Andreasson K, Lee S, Lagishetty V, Wu M, Howlett N, English J, et al.
ACR Open Rheumatol
. 2022 Feb;
4(5):417-425.
PMID: 35174673
Objective: The study objective was to examine alterations in gastrointestinal (GI) microbial composition in patients with systemic sclerosis (SSc) and to investigate the relationship between SSc features and GI microbiota...
2.
Shieh A, Lee S, Lagishetty V, Gottleib C, Jacobs J, Adams J
J Clin Endocrinol Metab
. 2021 Aug;
106(12):3464-3476.
PMID: 34343292
Context: Experimental studies suggest that vitamin D receptor signaling may benefit the gut microbiome. In humans, whether vitamin D supplementation directly alters the gut microbiome is not well studied. Objective:...
3.
Fox M, Lee S, Wiley K, Lagishetty V, Sandman C, Jacobs J, et al.
Dev Psychopathol
. 2021 Jun;
34(5):1914-1925.
PMID: 34108055
Perturbations to the gut microbiome are implicated in altered neurodevelopmental trajectories that may shape life span risk for emotion dysregulation and affective disorders. However, the sensitive periods during which the...
4.
Lee S, Dong T, Krause-Sorio B, Siddarth P, Milillo M, Lagishetty V, et al.
Int Psychogeriatr
. 2021 Mar;
34(1):33-45.
PMID: 33757609
Objectives: (1) To investigate if gut microbiota can be a predictor of remission in geriatric depression and to identify features of the gut microbiota that is associated with remission. (2)...
5.
Lee S, Te S, Breen E, Olmstead R, Irwin M, Cho J
World J Biol Psychiatry
. 2019 Sep;
21(8):634-641.
PMID: 31552779
Circulating cytokines have been associated with depression, but their detection has limitations, which may be overcome by direct detection of intracellular cytokines (ICCs) after lipopolysaccharide (LPS) stimulation . This study...
6.
Choi H, Calvert C, Husain N, Huss D, Barsi J, Deverman B, et al.
Development
. 2016 Oct;
143(19):3632-3637.
PMID: 27702788
In situ hybridization methods are used across the biological sciences to map mRNA expression within intact specimens. Multiplexed experiments, in which multiple target mRNAs are mapped in a single sample,...
7.
Donaldson G, Lee S, Mazmanian S
Nat Rev Microbiol
. 2015 Oct;
14(1):20-32.
PMID: 26499895
Animals assemble and maintain a diverse but host-specific gut microbial community. In addition to characteristic microbial compositions along the longitudinal axis of the intestines, discrete bacterial communities form in microhabitats,...
8.
Lee S, Donaldson G, Mikulski Z, Boyajian S, Ley K, Mazmanian S
Nature
. 2013 Aug;
501(7467):426-9.
PMID: 23955152
Mammals harbour a complex gut microbiome, comprising bacteria that confer immunological, metabolic and neurological benefits. Despite advances in sequence-based microbial profiling and myriad studies defining microbiome composition during health and...
9.
Huang J, Lee S, Mazmanian S
Anaerobe
. 2011 Jun;
17(4):137-41.
PMID: 21664470
The mammalian gastrointestinal tract harbors a vast microbial ecosystem, known as the microbiota, which benefits host biology. Bacteroides fragilis is an important anaerobic gut commensal of humans that prevents and...
10.
Round J, Lee S, Li J, Tran G, Jabri B, Chatila T, et al.
Science
. 2011 Apr;
332(6032):974-7.
PMID: 21512004
Mucosal surfaces constantly encounter microbes. Toll-like receptors (TLRs) mediate recognition of microbial patterns to eliminate pathogens. By contrast, we demonstrate that the prominent gut commensal Bacteroides fragilis activates the TLR...