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Sarath Babu Nukala

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Citations 94
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Recent Articles
1.
Han Z, Yan G, Jousma J, Nukala S, Amiri M, Kiniry S, et al.
J Clin Invest . 2025 Feb; 135(3). PMID: 39895626
Translational control shapes the proteome and is particularly important in regulating gene expression under stress. A key source of endothelial stress is treatment with tyrosine kinase inhibitors (TKIs), which lowers...
2.
Sridhar A, DeSantiago J, Chen H, Pavel M, Ly O, Owais A, et al.
J Clin Invest . 2024 Aug; 134(18). PMID: 39146015
Obesity is linked to an increased risk of atrial fibrillation (AF) via increased oxidative stress. While NADPH oxidase 2 (NOX2), a major source of oxidative stress and reactive oxygen species...
3.
Yan G, Han Z, Kwon Y, Jousma J, Nukala S, Prosser B, et al.
Circ Res . 2024 Feb; 134(5):482-501. PMID: 38323474
Background: Mitochondrial dysfunction is a primary driver of cardiac contractile failure; yet, the cross talk between mitochondrial energetics and signaling regulation remains obscure. Ponatinib, a tyrosine kinase inhibitor used to...
4.
Nukala S, Jousma J, Yan G, Han Z, Kwon Y, Cho Y, et al.
Cardiovasc Res . 2023 Jun; 119(10):1997-2013. PMID: 37267414
Aims: Novel cancer therapies leading to increased survivorship of cancer patients have been negated by a concomitant rise in cancer therapies-related cardiovascular toxicities. Sunitinib, a first line multi-receptor tyrosine kinase...
5.
Jousma J, Han Z, Yan G, Nukala S, Kwon Y, Le H, et al.
Epigenomics . 2022 Oct; 14(19):1139-1155. PMID: 36314267
This study aimed to characterize the N-methyladenosine epitranscriptomic profile induced by mono(2-ethylhexyl) phthalate (MEHP) exposure using a human-induced pluripotent stem cell-derived endothelial cell model. A multiomic approach was employed by...
6.
Nukala S, Jousma J, Cho Y, Lee W, Ong S
Cell Biosci . 2022 Mar; 12(1):24. PMID: 35246252
Cancer is one of the leading causes of morbidity and mortality worldwide. Significant improvements in the modern era of anticancer therapeutic strategies have increased the survival rate of cancer patients....
7.
Nukala S, Tura-Ceide O, Aldini G, Smolders V, Blanco I, Peinado V, et al.
Sci Rep . 2021 Mar; 11(1):5583. PMID: 33692478
Chronic thromboembolic pulmonary hypertension (CTEPH) is a vascular disease characterized by the presence of organized thromboembolic material in pulmonary arteries leading to increased vascular resistance, heart failure and death. Dysfunction...
8.
Kwon Y, Nukala S, Srivastava S, Miyamoto H, Ismail N, Jousma J, et al.
Stem Cell Res Ther . 2020 Dec; 11(1):514. PMID: 33256833
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global pandemic. The prevalence/severity of COVID-19 is higher among patients with cardiovascular risk factors....
9.
Kwon Y, Nukala S, Srivastava S, Miyamoto H, Ismail N, Rehman J, et al.
bioRxiv . 2020 Jul; PMID: 32637965
The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a worldwide pandemic. Early data suggest that the prevalence and severity...
10.
Radrezza S, Baron G, Nukala S, Depta G, Aldini G, Carini M, et al.
J Pharm Biomed Anal . 2020 Mar; 185:113199. PMID: 32146287
Hyaluronic acid (HA) is physiologically synthesized by several human cells types but it is also a widespread ingredient of commercial products, from pharmaceuticals to cosmetics. Despite its extended use, the...