Sarah W Y Lok
Overview
Explore the profile of Sarah W Y Lok including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
99
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Tang Q, Xiao D, Veviorskiy A, Xin Y, Lok S, Pulous F, et al.
Aging Dis
. 2025 Feb;
PMID: 39965245
Assessing impact on the hallmarks of aging has emerged as a novel method for prioritizing dual-purpose longevity therapeutic targets and developing drugs simultaneously targeting aging and disease. Cellular senescence, a...
2.
Zou Y, Yiu W, Lok S, Ma J, Feng Y, Lai K, et al.
J Am Soc Nephrol
. 2024 Dec;
PMID: 39656554
No abstract available.
3.
Long Non-coding RNA NEAT1 , NOD-Like Receptor Family Protein 3 Inflammasome, and Acute Kidney Injury
Xue R, Yiu W, Chan K, Lok S, Zou Y, Ma J, et al.
J Am Soc Nephrol
. 2024 Aug;
35(8):998-1015.
PMID: 39088708
No abstract available.
4.
Lok S, Yiu W, Zou Y, Xue R, Li H, Ma J, et al.
Nephrol Dial Transplant
. 2023 Mar;
38(10):2232-2247.
PMID: 36914214
Background: Thromboembolic events are prevalent in chronic kidney disease (CKD) patients due to increased thrombin generation leading to a hypercoagulable state. We previously demonstrated that inhibition of protease-activated receptor-1 (PAR-1)...
5.
Yiu W, Lok S, Xue R, Chen J, Lai K, Lan H, et al.
Clin Sci (Lond)
. 2023 Jan;
137(5):317-331.
PMID: 36705251
Kidney inflammation contributes to the progression of chronic kidney disease (CKD). Modulation of Toll-like receptor 4 (TLR4) signaling is a potential therapeutic strategy for this pathology, but the regulatory mechanisms...
6.
Li H, Leung J, Yiu W, Chan L, Li B, Lok S, et al.
Cell Death Dis
. 2022 Dec;
13(12):1061.
PMID: 36539406
Mitochondria take part in a network of intracellular processes that regulate homeostasis. Defects in mitochondrial function are key pathophysiological changes during AKI. Although Wnt/β-catenin signaling mediates mitochondrial dysfunction in chronic...
7.
Li B, Leung J, Chan L, Li H, Yiu W, Lok S, et al.
Mol Ther Nucleic Acids
. 2021 Dec;
26():1280-1290.
PMID: 34853727
Lipotoxicity has been implicated in the pathogenesis of obesity-related kidney damage and propagates chronic kidney injury like diabetic kidney disease; however, the underlying mechanisms have not yet been fully elucidated....
8.
Yiu W, Li Y, Lok S, Chan K, Chan L, Leung J, et al.
Clin Sci (Lond)
. 2021 Jan;
135(3):429-446.
PMID: 33458750
Kallistatin is a multiple functional serine protease inhibitor that protects against vascular injury, organ damage and tumor progression. Kallistatin treatment reduces inflammation and fibrosis in the progression of chronic kidney...
9.
Lok S, Yiu W, Li H, Xue R, Zou Y, Li B, et al.
Clin Sci (Lond)
. 2020 Oct;
134(21):2873-2891.
PMID: 33078834
Protease-activated receptor (PAR)-1 has emerged as a key profibrotic player in various organs including kidney. PAR-1 activation leads to deposition of extracellular matrix (ECM) proteins in the tubulointerstitium and induction...
10.
Li B, Leung J, Chan L, Yiu W, Li Y, Lok S, et al.
Stem Cells Transl Med
. 2019 May;
8(9):898-910.
PMID: 31054183
Recent advances in the understanding of lipid metabolism suggest a critical role of endoplasmic reticulum (ER) stress in obesity-induced kidney injury. Hepatocyte growth factor (HGF) is a pleiotropic cytokine frequently...