Joseph C K Leung
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Explore the profile of Joseph C K Leung including associated specialties, affiliations and a list of published articles.
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93
Citations
2011
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Recent Articles
1.
Li H, Leung J, Yiu W, Chan L, Li B, Lok S, et al.
Cell Death Dis
. 2022 Dec;
13(12):1061.
PMID: 36539406
Mitochondria take part in a network of intracellular processes that regulate homeostasis. Defects in mitochondrial function are key pathophysiological changes during AKI. Although Wnt/β-catenin signaling mediates mitochondrial dysfunction in chronic...
2.
Li B, Leung J, Chan L, Li H, Yiu W, Lok S, et al.
Mol Ther Nucleic Acids
. 2021 Dec;
26():1280-1290.
PMID: 34853727
Lipotoxicity has been implicated in the pathogenesis of obesity-related kidney damage and propagates chronic kidney injury like diabetic kidney disease; however, the underlying mechanisms have not yet been fully elucidated....
3.
Yiu W, Chan K, Chan L, Leung J, Lai K, Tang S
Front Physiol
. 2021 Apr;
12:650888.
PMID: 33790807
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase involved in signal transduction in a variety of immune responses. It has been demonstrated that Syk plays a pathogenic role in...
4.
Yiu W, Li Y, Lok S, Chan K, Chan L, Leung J, et al.
Clin Sci (Lond)
. 2021 Jan;
135(3):429-446.
PMID: 33458750
Kallistatin is a multiple functional serine protease inhibitor that protects against vascular injury, organ damage and tumor progression. Kallistatin treatment reduces inflammation and fibrosis in the progression of chronic kidney...
5.
Lok S, Yiu W, Li H, Xue R, Zou Y, Li B, et al.
Clin Sci (Lond)
. 2020 Oct;
134(21):2873-2891.
PMID: 33078834
Protease-activated receptor (PAR)-1 has emerged as a key profibrotic player in various organs including kidney. PAR-1 activation leads to deposition of extracellular matrix (ECM) proteins in the tubulointerstitium and induction...
6.
Li B, Leung J, Chan L, Yiu W, Tang S
Prog Lipid Res
. 2019 Dec;
77:101020.
PMID: 31870728
Obesity is featured by chronic systemic low-grade inflammation that eventually contributes to the development of insulin resistance. Toll-like receptor 4 (TLR4) is an important mediator that triggers the innate immune...
7.
Li B, Leung J, Chan L, Yiu W, Li Y, Lok S, et al.
Stem Cells Transl Med
. 2019 May;
8(9):898-910.
PMID: 31054183
Recent advances in the understanding of lipid metabolism suggest a critical role of endoplasmic reticulum (ER) stress in obesity-induced kidney injury. Hepatocyte growth factor (HGF) is a pleiotropic cytokine frequently...
8.
Leung J, Lai K, Tang S
Semin Nephrol
. 2018 Sep;
38(5):485-495.
PMID: 30177020
IgA nephropathy (IgAN), a common primary glomerulonephritis worldwide, is associated with a substantial risk of progression to end-stage renal failure. The disease runs a highly variable clinical course with frequent...
9.
Wong D, Yiu W, Chan K, Li Y, Li B, Lok S, et al.
Kidney Int
. 2018 Apr;
93(6):1367-1383.
PMID: 29605095
Imbalance of Wnt/β-catenin signaling in renal cells is associated with renal dysfunction, yet the precise mechanism is poorly understood. Previously we observed activated Wnt/β-catenin signaling in renal tubules during proteinuric...
10.
Yiu W, Li R, Wong D, Wu H, Chan K, Chan L, et al.
Nephrol Dial Transplant
. 2018 Jan;
33(8):1323-1332.
PMID: 29294056
Background: Complement C5 mediates pro-inflammatory responses in many immune-related renal diseases. Given that the C5a level is elevated in diabetes, we investigated whether activation of C5a/C5aR signalling plays a pathogenic...