Sarah R Chadwick
Overview
Explore the profile of Sarah R Chadwick including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
106
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0
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Recent Articles
1.
Chadwick S, Stack-Couture S, Berg M, Di Gregorio S, Lung B, Genereaux J, et al.
Mol Biol Cell
. 2024 Dec;
36(2):ar13.
PMID: 39661468
Cells counter accumulation of misfolded secretory proteins in the endoplasmic reticulum (ER) through activation of the Unfolded Protein Response (UPR). Small molecules termed chemical chaperones can promote protein folding to...
2.
Chadwick S, Barreda D, Wu J, Ye G, Yusuf B, Ren D, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(8):e2309465121.
PMID: 38354262
Phagocytes promptly resolve ingested targets to replenish lysosomes and maintain their responsiveness. The resolution process requires that degradative hydrolases, solute transporters, and proteins involved in lipid traffic are delivered and...
3.
Chadwick S, Grinstein S, Freeman S
Curr Opin Cell Biol
. 2021 Mar;
71:77-86.
PMID: 33706237
Endocytic traffic is a complex and elegant operation involving cargo sorting, membrane budding and tubulation, generation of force, and the formation of organellar contacts. The role of specific proteins and...
4.
Chadwick S, Wu J, Freeman S
Cell Physiol Biochem
. 2021 Jan;
55(S1):1-24.
PMID: 33385319
The regulation of cellular volume in response to osmotic change has largely been studied at the whole cell level. Such regulation occurs by the inhibition or activation of ionic and...
5.
Chadwick S, Fazio E, Etedali-Zadeh P, Genereaux J, Duennwald M, Lajoie P
Curr Genet
. 2019 Jul;
66(1):263-277.
PMID: 31346745
Progressive impairment of proteostasis and accumulation of toxic misfolded proteins are associated with the cellular aging process. Here, we employed chronologically aged yeast cells to investigate how activation of the...
6.
Chadwick S, Lajoie P
Front Cell Dev Biol
. 2019 Jun;
7:84.
PMID: 31231647
Multiple factors lead to proteostatic perturbations, often resulting in the aberrant accumulation of toxic misfolded proteins. Cells, from yeast to humans, can respond to sudden accumulation of secretory proteins within...
7.
Jiang Y, Chadwick S, Lajoie P
Brain Res
. 2016 Apr;
1648(Pt B):650-657.
PMID: 27040914
Accumulation of misfolded proteins is a hallmark of many human diseases, including several incurable neurological disorders, such as Huntington's disease (HD). In HD, expansion of a polyglutamine stretch within the...
8.
Chadwick S, Pananos A, Di Gregorio S, Park A, Etedali-Zadeh P, Duennwald M, et al.
Traffic
. 2016 Mar;
17(6):689-703.
PMID: 26939796
Saccharomyces cerevisiae is a well-established model organism to study the mechanisms of longevity. One of the two aging paradigms studied in yeast is termed chronological lifespan (CLS). CLS is defined...