Sarah M Wignall
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Explore the profile of Sarah M Wignall including associated specialties, affiliations and a list of published articles.
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27
Citations
470
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Recent Articles
1.
Czajkowski E, Zou Y, Divekar N, Wignall S
PLoS Genet
. 2024 Sep;
20(9):e1011373.
PMID: 39226307
Although centrosomes help organize spindles in most cell types, oocytes of most species lack these structures. During acentrosomal spindle assembly in C. elegans oocytes, microtubule minus ends are sorted outwards...
2.
Narula J, Wignall S
bioRxiv
. 2024 Aug;
PMID: 39131294
Sexual reproduction relies on meiosis, a specialized cell division program that produces haploid gametes. Oocytes of most organisms lack centrosomes, and therefore chromosome segregation is mediated by acentrosomal spindles. Here,...
3.
Czajkowski E, Divekar N, Wignall S
bioRxiv
. 2023 Dec;
PMID: 38045228
Although centrosomes help organize spindles in most cell types, oocytes of most species lack these structures. During acentrosomal spindle assembly in oocytes, microtubule minus ends are sorted outwards away from...
4.
Cavin-Meza G, Mullen T, Czajkowski E, Wolff I, Divekar N, Finkle J, et al.
PLoS Genet
. 2022 Nov;
18(11):e1010489.
PMID: 36449516
During mitosis, centrosomes serve as microtubule organizing centers that guide the formation of a bipolar spindle. However, oocytes of many species lack centrosomes; how meiotic spindles establish and maintain these...
5.
Horton H, Divekar N, Wignall S
Mol Biol Cell
. 2022 Oct;
33(14):br25.
PMID: 36222840
Although end-on microtubule-kinetochore attachments typically drive chromosome alignment, oocytes do not form these connections. Instead, microtubule bundles run laterally alongside chromosomes and a ring-shaped protein complex facilitates congression (the "ring...
6.
Wolff I, Hollis J, Wignall S
Mol Biol Cell
. 2022 May;
33(8):ar71.
PMID: 35594182
During the meiotic divisions in oocytes, microtubules are sorted and organized by motor proteins to generate a bipolar spindle in the absence of centrosomes. In most organisms, kinesin-5 family members...
7.
Sue A, Wignall S, Woodruff T, OHalloran T
J Assist Reprod Genet
. 2022 May;
39(6):1261-1276.
PMID: 35501415
Purpose: The requirement of zinc for the development and maturation of germ lines and reproductive systems is deeply conserved across evolution. The nematode Caenorhabditis elegans offers a tractable platform to...
8.
Mendoza A, Sue A, Antipova O, Vogt S, Woodruff T, Wignall S, et al.
Biol Reprod
. 2022 Apr;
107(2):406-418.
PMID: 35466369
Zinc influx and efflux events are essential for meiotic progression in oocytes of several mammalian and amphibian species, but it is less clear whether this evolutionary conservation of zinc signals...
9.
Cavin-Meza G, Kwan M, Wignall S
Elife
. 2022 Feb;
11.
PMID: 35147496
While centrosomes organize spindle poles during mitosis, oocyte meiosis can occur in their absence. Spindles in human oocytes frequently fail to maintain bipolarity and consequently undergo chromosome segregation errors, making...
10.
Wolff I, Divekar N, Wignall S
Methods Mol Biol
. 2022 Jan;
2415:19-35.
PMID: 34972943
The nematode Caenorhabditis elegans is a widely used model organism for the study of mitotic and meiotic cell division. These self-fertilizing worms are particularly advantageous for such studies because they...