Sarah M Prophet
Overview
Explore the profile of Sarah M Prophet including associated specialties, affiliations and a list of published articles.
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6
Citations
73
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Recent Articles
1.
Kuiper E, Prophet S, Schlieker C
FEBS Lett
. 2023 Aug;
597(20):2534-2545.
PMID: 37620293
The nuclear pore complex (NPC) is among the most elaborate protein complexes in eukaryotes. While ribosomes and proteasomes are known to require dedicated assembly machinery, our understanding of NPC assembly...
2.
Prophet S, Rampello A, Niescier R, Gentile J, Mallik S, Koleske A, et al.
Nat Cell Biol
. 2022 Oct;
24(11):1630-1641.
PMID: 36302970
DYT1 dystonia is a debilitating neurological movement disorder arising from mutation in the AAA+ ATPase TorsinA. The hallmark of Torsin dysfunction is nuclear envelope blebbing resulting from defects in nuclear...
3.
Prophet S, Naughton B, Schlieker C
Int J Mol Sci
. 2022 May;
23(9).
PMID: 35563018
DYT1 dystonia is a debilitating neurological movement disorder that arises upon Torsin ATPase deficiency. Nuclear envelope (NE) blebs that contain FG-nucleoporins (FG-Nups) and K48-linked ubiquitin are the hallmark phenotype of...
4.
Rampello A, Laudermilch E, Vishnoi N, Prophet S, Shao L, Zhao C, et al.
J Cell Biol
. 2020 Apr;
219(6).
PMID: 32342107
Nuclear envelope herniations (blebs) containing FG-nucleoporins and ubiquitin are the phenotypic hallmark of Torsin ATPase manipulation. Both the dynamics of blebbing and the connection to nuclear pore biogenesis remain poorly...
5.
Rampello A, Prophet S, Schlieker C
Biomolecules
. 2020 Mar;
10(3).
PMID: 32204310
Torsin ATPases are members of the AAA+ (ATPases associated with various cellular activities) superfamily of proteins, which participate in essential cellular processes. While AAA+ proteins are ubiquitously expressed and demonstrate...
6.
Prophet S, Schlieker C
J Clin Invest
. 2019 Oct;
129(11):4576-4579.
PMID: 31589164
Mutations affecting the integrity of the essential torsin ATPase/cofactor system have been identified in a steadily increasing number of congenital disorders. Since most of these mutations affect brain function, much...