Sarah M Bernhard
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Explore the profile of Sarah M Bernhard including associated specialties, affiliations and a list of published articles.
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17
Citations
161
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Recent Articles
1.
Varga B, Bernhard S, El Daibani A, Zaidi S, Lam J, Aguilar J, et al.
Nat Commun
. 2025 Mar;
16(1):2518.
PMID: 40082451
Chronic pain and opioid overdose deaths highlight the need for non-addictive analgesics with novel mechanisms. The δ opioid receptor (δOR) is a promising target, as it lacks the respiratory depression...
2.
Andreoti T, Maiolo M, Tuleja A, Doring Y, Schaller A, Vassella E, et al.
Am J Med Genet A
. 2024 Oct;
197(2):e63883.
PMID: 39376044
PIK3CA variants are known to cause vascular malformations. We were interested in studying the phenotypic spectrum, the location within the PIK3CA gene, and the variant allele frequency (VAF) of somatic...
3.
Ople R, Ramos-Gonzalez N, Li Q, Sobecks B, Aydin D, Powers A, et al.
ACS Cent Sci
. 2024 Sep;
10(8):1490-1503.
PMID: 39220695
The mu opioid receptor (μOR) is a target for clinically used analgesics. However, adverse effects, such as respiratory depression and physical dependence, necessitate the development of alternative treatments. Recently we...
4.
Che T, Varga B, Bernhard S, El Daibani A, Zaidi S, Lam J, et al.
Res Sq
. 2024 Jul;
PMID: 39070616
The persistence of chronic pain and continuing overdose deaths from pain-relieving opioids targeting μ opioid receptor (μOR) have fueled the need for reliable long-term analgesics which use different targets and...
5.
Kapp F, Bazgir F, Mahammadzade N, Mehrabipour M, Vassella E, Bernhard S, et al.
Angiogenesis
. 2024 Jul;
27(4):739-752.
PMID: 38969873
Arteriovenous malformations (AVM) are benign vascular anomalies prone to pain, bleeding, and progressive growth. AVM are mainly caused by mosaic pathogenic variants of the RAS-MAPK pathway. However, a causative variant...
6.
Bernhard S, Kammer F, Roumet M, Haupt F, Tuleja A, Schindewolf M, et al.
Cardiovasc Diagn Ther
. 2024 May;
14(2):283-293.
PMID: 38716311
Background: Venous malformation (VM) is the most frequent type of congenital vascular malformation. In terms of functional outcome local sclerotherapy remains the most important therapeutic tool. For planning and correct...
7.
Bernhard S, Han J, Che T
FEBS J
. 2023 Dec;
291(13):2784-2791.
PMID: 38151714
Receptor-G protein promiscuity is frequently observed in class A G protein-coupled receptors (GPCRs). In particular, GPCRs can couple with G proteins from different families (Gαs, Gαq/11, Gαi/o, and Gα12/13) or...
8.
9.
Han J, Zhang J, Nazarova A, Bernhard S, Krumm B, Zhao L, et al.
Nature
. 2023 May;
617(7960):417-425.
PMID: 37138078
The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not only pain but also addiction and affective disorders. However, the development of KOR analgesics has been hindered...
10.
El Daibani A, Paggi J, Kim K, Laloudakis Y, Popov P, Bernhard S, et al.
Nat Commun
. 2023 Mar;
14(1):1338.
PMID: 36906681
The κ-opioid receptor (KOR) has emerged as an attractive drug target for pain management without addiction, and biased signaling through particular pathways of KOR may be key to maintaining this...