Sarah L Davies
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Explore the profile of Sarah L Davies including associated specialties, affiliations and a list of published articles.
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15
Citations
330
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Recent Articles
1.
Davies S, Davies S, Cuthbertson D, Ward L, Ward L, Wassif W, et al.
Ann Clin Biochem
. 2025 Jan;
:45632251319984.
PMID: 39875127
Objectives: Primary aldosteronism (PA) is a common but under-recognised cause of secondary hypertension. Early diagnosis with targeted medical and/or surgical intervention is important to prevent irreversible end-organ damage. An Endocrine...
2.
Antonios G, Borgers H, Richard B, Brauss A, Meissner J, Weggen S, et al.
Sci Rep
. 2015 Dec;
5:17338.
PMID: 26626428
Full-length Aβ1-42 and Aβ1-40, N-truncated pyroglutamate Aβ3-42 and Aβ4-42 are major variants in the Alzheimer brain. Aβ4-42 has not been considered as a therapeutic target yet. We demonstrate that the...
3.
Davies S, Hill C, Bailey L, Davison A, Milan A
Ann Clin Biochem
. 2015 Apr;
53(Pt 2):292-4.
PMID: 25838413
Background: Deriving and validating local adjusted calcium equations is important for ensuring appropriate calcium status classification. We investigated the impact on our local adjusted calcium equation of a change in...
4.
Davies S, Lovelady C, Grainger R, Racher A, Young R, James D
Biotechnol Bioeng
. 2012 Jul;
110(1):260-74.
PMID: 22833427
In this study, we address the hypothesis that it is possible to exploit genetic/functional variation in parental Chinese hamster ovary (CHO) cell populations to isolate clonal derivatives that exhibit superior,...
5.
Davies S, OCallaghan P, McLeod J, Pybus L, Sung Y, Rance J, et al.
Biotechnol Prog
. 2011 Sep;
27(6):1689-99.
PMID: 21882365
In this study, we systematically compare two vector design strategies for recombinant monoclonal antibody (Mab) synthesis by Chinese hamster ovary (CHO) cells; a dual open reading frame (ORF) expression vector...
6.
Pruzina S, Williams G, Kaneva G, Davies S, Martin-Lopez A, Bruggemann M, et al.
Protein Eng Des Sel
. 2011 Aug;
24(10):791-9.
PMID: 21810921
Mice carrying human immunoglobulin transloci were immunised with HIV-1 gp140 antigen to gain insight into the range and nature of human monoclonal antibodies (mAbs) that can be elicited from such...
7.
Flashman E, Davies S, Yeoh K, Schofield C
Biochem J
. 2010 Jan;
427(1):135-42.
PMID: 20055761
The HIF (hypoxia-inducible factor) hydroxylases [PHDs or EGLNs (prolyl hydroxylases), which in humans are PHD isoforms 1-3, and FIH (factor inhibiting HIF)] regulate HIF levels and activity. These enzymes are...
8.
Davies S, Best L, Brown P
Pflugers Arch
. 2009 Feb;
458(3):621-9.
PMID: 19214560
Ion transport activity in pancreatic alpha-cells was assessed by studying cell volume regulation in response to anisotonic solutions. Cell volume was measured by a video imaging method, and cells were...
9.
Davies S, Gibbons C, Steward M, Ward D
Biochim Biophys Acta
. 2008 Jun;
1778(10):2318-24.
PMID: 18573233
The calcium-sensing receptor (CaR) is expressed on intestinal epithelial serosal membrane and in Caco-2 cells. In renal epithelium, CaR expressed on the basolateral membrane acts to limit excess tubular Ca2+...
10.
Davies S, Ozawa A, McCormick W, Dvorak M, Ward D
J Biol Chem
. 2007 Mar;
282(20):15048-56.
PMID: 17376781
The agonist sensitivity of the calcium-sensing receptor (CaR) can be altered by protein kinase C (PKC), with CaR residue Thr(888) contributing significantly to this effect. To determine whether CaR(T888) is...