Sarah E van Rossum-Fikkert
Overview
Explore the profile of Sarah E van Rossum-Fikkert including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
692
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Recent Articles
1.
Paul M, Sidhu A, Liang Y, van Rossum-Fikkert S, Odijk H, Zelensky A, et al.
Elife
. 2021 Jul;
10.
PMID: 34254584
Breast cancer type two susceptibility protein (BRCA2) is an essential protein in genome maintenance, homologous recombination (HR), and replication fork protection. Its function includes multiple interaction partners and requires timely...
2.
Sidhu A, Grosbart M, Sanchez H, Verhagen B, van der Zon N, Ristic D, et al.
Nucleic Acids Res
. 2020 Aug;
48(17):9649-9659.
PMID: 32785644
BRCA2 is a key breast cancer associated protein that is predicted to have interspersed regions of intrinsic disorder. Intrinsic disorder coupled with large size likely allows BRCA2 to sample a...
3.
Sanchez H, Paul M, Grosbart M, van Rossum-Fikkert S, Lebbink J, Kanaar R, et al.
Nucleic Acids Res
. 2017 Feb;
45(8):4507-4518.
PMID: 28168276
The tumor suppressor BRCA2 is a large multifunctional protein mutated in 50-60% of familial breast cancers. BRCA2 interacts with many partners and includes multiple regions with potentially disordered structure. In...
4.
van den Doel P, Prieto V, van Rossum-Fikkert S, Schaftenaar W, Latimer E, Howard L, et al.
BMC Public Health
. 2015 Sep;
15:851.
PMID: 26336090
No abstract available.
5.
van den Doel P, Prieto V, van Rossum-Fikkert S, Schaftenaar W, Latimer E, Howard L, et al.
BMC Vet Res
. 2015 Aug;
11:203.
PMID: 26268467
Background: Elephants are classified as critically endangered animals by the International Union for Conservation of Species (IUCN). Elephant endotheliotropic herpesvirus (EEHV) poses a large threat to breeding programs of captive...
6.
Notenboom V, Hibbert R, van Rossum-Fikkert S, Olsen J, Mann M, Sixma T
Nucleic Acids Res
. 2007 Aug;
35(17):5819-30.
PMID: 17720710
Rad18 is a ubiquitin E3 ligase that monoubiquitinates PCNA on stalled replications forks. This allows recruitment of damage-tolerant polymerases for damage bypass and DNA repair. In this activity, the Rad18...
7.
Celie P, Kasheverov I, Mordvintsev D, Hogg R, van Nierop P, van Elk R, et al.
Nat Struct Mol Biol
. 2005 Jun;
12(7):582-8.
PMID: 15951818
Conotoxins (Ctx) form a large family of peptide toxins from cone snail venoms that act on a broad spectrum of ion channels and receptors. The subgroup alpha-Ctx specifically and selectively...
8.
Celie P, Klaassen R, van Rossum-Fikkert S, van Elk R, van Nierop P, Smit A, et al.
J Biol Chem
. 2005 May;
280(28):26457-66.
PMID: 15899893
The crystal structure of acetylcholine-binding protein (AChBP) from the mollusk Lymnaea stagnalis is the established model for the ligand binding domains of the ligand-gated ion channel family, which includes nicotinic...
9.
Celie P, van Rossum-Fikkert S, van Dijk W, Brejc K, Smit A, Sixma T
Neuron
. 2004 Mar;
41(6):907-14.
PMID: 15046723
Nicotinic acetylcholine receptors are prototypes for the pharmaceutically important family of pentameric ligand-gated ion channels. Here we present atomic resolution structures of nicotine and carbamylcholine binding to AChBP, a water-soluble...