Sarah E Johnstone
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Explore the profile of Sarah E Johnstone including associated specialties, affiliations and a list of published articles.
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17
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5403
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Recent Articles
1.
Amodeo M, Eyler C, Johnstone S
Curr Opin Genet Dev
. 2025 Jan;
91:102307.
PMID: 39862605
In modern cancer biology, Hanahan and Weinberg's classic depiction of the Hallmarks of Cancer serves as a heuristic for understanding malignant phenotypes [1]. Genetic determinants of these phenotypes promote cancer...
2.
Cerda-Smith C, Hutchinson H, Liu A, Goel V, Sept C, Kim H, et al.
bioRxiv
. 2023 Oct;
PMID: 37786671
Enhancers possess both structural elements mediating promoter looping and functional elements mediating gene expression. Traditional models of enhancer-mediated gene regulation imply genomic overlap or immediate adjacency of these elements. We...
3.
Rahme G, Javed N, Puorro K, Xin S, Hovestadt V, Johnstone S, et al.
Cell
. 2023 Jul;
186(17):3674-3685.e14.
PMID: 37494934
Epigenetic lesions that disrupt regulatory elements represent potential cancer drivers. However, we lack experimental models for validating their tumorigenic impact. Here, we model aberrations arising in isocitrate dehydrogenase-mutant gliomas, which...
4.
Bevill S, Casani-Galdon S, El Farran C, Cytrynbaum E, Macias K, Oldeman S, et al.
Cell Genom
. 2023 Jul;
3(7):100321.
PMID: 37492096
Amplification of MDM2 on supernumerary chromosomes is a common mechanism of P53 inactivation across tumors. Here, we investigated the impact of MDM2 overexpression on chromatin, gene expression, and cellular phenotypes...
5.
Johnstone S, Gladyshev V, Aryee M, Bernstein B
Science
. 2022 Dec;
378(6626):1276-1277.
PMID: 36548410
Global methylation changes in aging cells affect cancer risk and tissue homeostasis.
6.
Siegenfeld A, Roseman S, Roh H, Lue N, Wagen C, Zhou E, et al.
Nat Commun
. 2022 Jul;
13(1):4199.
PMID: 35859152
The genome can be divided into two spatially segregated compartments, A and B, which partition active and inactive chromatin states. While constitutive heterochromatin is predominantly located within the B compartment...
7.
Qi Y, Reyes A, Johnstone S, Aryee M, Bernstein B, Zhang B
Biophys J
. 2020 Oct;
119(9):1905-1916.
PMID: 33086041
Chromosomes are positioned nonrandomly inside the nucleus to coordinate with their transcriptional activity. The molecular mechanisms that dictate the global genome organization and the nuclear localization of individual chromosomes are...
8.
Johnstone S, Reyes A, Qi Y, Adriaens C, Hegazi E, Pelka K, et al.
Cell
. 2020 Aug;
182(6):1474-1489.e23.
PMID: 32841603
Widespread changes to DNA methylation and chromatin are well documented in cancer, but the fate of higher-order chromosomal structure remains obscure. Here we integrated topological maps for colon tumors and...
9.
Kurzawa P, Mullen J, Chen Y, Johnstone S, Deshpande V, Chebib I, et al.
Am J Surg Pathol
. 2020 Jan;
44(6):799-804.
PMID: 31985499
Myogenic differentiation (MD) has been claimed to be a poor prognostic factor in dedifferentiated liposarcoma (DDLPS). To validate this, the prognostic significance of MD in a uniformly treated cohort of...
10.
Williams S, Juratli T, Castro B, Lazaro T, Gill C, Nayyar N, et al.
J Neurol Surg B Skull Base
. 2019 Nov;
80(6):562-567.
PMID: 31750041
Posterior fossa meningiomas are surgically challenging tumors that are associated with high morbidity and mortality. We sought to investigate the anatomical distribution of clinically actionable mutations in posterior fossa meningioma...