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Sarah E Ewald

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Articles 31
Citations 1334
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Recent Articles
1.
Wei X, Qian W, Narasimhan H, Chan T, Liu X, Arish M, et al.
Science . 2025 Mar; 387(6738):eadq2509. PMID: 40048515
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolution and lung repair during severe respiratory...
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Ball A, Morgaenko K, Anbaei P, Ewald S, Pompano R
Cytokine . 2024 Aug; 183:156731. PMID: 39168064
Subunit vaccines drive immune cell-cell interactions in the lymph node (LN), yet it remains unclear how distinct adjuvants influence the chemokines responsible for this interaction in the tissue. Here, we...
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Keele G, Hay A, Holness N, Jash A, Ewald S, OConnor C, et al.
Haematologica . 2024 Jul; 109(11):3755-3759. PMID: 39021224
No abstract available.
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Nguyen Y, Sibley L, Przanowski P, Zhao X, Kovacs M, Wang S, et al.
J Neuroimmunol . 2024 Jul; 393:578402. PMID: 38996717
Few T cells infiltrate into primary brain tumors, fundamentally hampering the effectiveness of immunotherapy. We hypothesized that Toxoplasma gondii, a microorganism that naturally elicits a Th1 response in the brain,...
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Roosa C, Lempke S, Hannan R, Nicklow E, Sturek J, Ewald S, et al.
Adv Healthc Mater . 2024 Apr; 13(25):e2400249. PMID: 38648258
The inflammatory foreign body response (FBR) is the main driver of biomaterial implant failure. Current strategies to mitigate the onset of a FBR include modification of the implant surface, release...
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Zhao X, Lempke S, Urban Arroyo J, Brown I, Yin B, Magaj M, et al.
Nat Commun . 2024 Mar; 15(1):2698. PMID: 38538595
Toxoplasma gondii is an obligate intracellular parasite of rodents and humans. Interferon-inducible guanylate binding proteins (GBPs) are mediators of T. gondii clearance, however, this mechanism is incomplete. Here, using automated...
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Mallikarjun V, Yin B, Caggiano L, Blimbaum S, Pavelec C, Holmes J, et al.
J Mol Cell Cardiol . 2023 Nov; 186:1-15. PMID: 37951204
Myocardial infarction (MI) results from occlusion of blood supply to the heart muscle causing death of cardiac muscle cells. Following myocardial infarction (MI), extracellular matrix deposition and scar formation mechanically...
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May D, Taha F, Child M, Ewald S
Trends Parasitol . 2023 Oct; 39(12):1074-1086. PMID: 37839913
Protozoan pathogens such as Plasmodium spp., Leishmania spp., Toxoplasma gondii, and Trypanosoma spp. are often associated with high-mortality, acute and chronic diseases of global health concern. For transmission and immune...
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Zhao X, Lempke S, Urban Arroyo J, Yin B, Holness N, Smiley J, et al.
bioRxiv . 2023 Aug; PMID: 37546987
is an obligate intracellular, protozoan pathogen of rodents and humans. ability to grow within cells and evade cell-autonomous immunity depends on the integrity of the parasitophorous vacuole (PV). Interferon-inducible guanylate...